胃肠道肿瘤术中植入氟尿嘧啶缓释剂的临床研究

目的探讨氟尿嘧啶缓释剂于胃肠道肿瘤术中应用的临床效果。方法 180例胃肠道肿瘤根治(Ⅱ、Ⅲ期)手术患者随机分成治疗组(80例)和对照组(100例),治疗组于术中手术创面血管旁等处植入氟尿嘧啶缓释剂。对照组于术中手术创面用蒸馏水冲洗。结果治疗组与对照组在骨髓抑制、肝肾功能异常、免疫抑制、切口感染、粘连性肠梗阻、腹腔内出血、吻合口瘘、化学性腹膜炎比较差异无显著性(P>0.05),两组1年生存率均为94.90%,差异无显著性。治疗组2年生存率(83.40%)明显高于对照组(66.00%),治疗组3年生存率(77.70%)明显高于对照组(54.00%),2、3年生存率比较差异有显著性(P<0.05)。结论胃肠道肿瘤术中植入氟尿嘧啶缓释剂可以明显提高患者生存率,是一种有效且毒副反应轻的腹腔化疗方法。

A clinical trial of sprinkling fluorouracil sustained release on incisions during gastrointestinal carcinoma operation

Objective To study the clinical effectiveness of applying fluorouracil sustained release in gastrointestinal neoplasms operations.Methods 180 patients undergone radical operations(Stages Ⅱ,Ⅲ) for gastrointestinal carcinoma were randomly divided into two groups: the treated group(n=80) and the control group(n=100).Patients in the treated group received fluorouracil sustained release sprinkled on the incisions and on the adjacent blood vessels of the wounds,et al.The wounds of the control group were cleaned with distilled water.Results In comparison of the incidences of myelosuppression,of the renal and hepatic functional abnormities,of the immunosuppresion,of infecuion of the incisional wounds,of adhesive intestinal obstruction,of abdominal hemorrhage, of anastomotic leakage and of chemical peritonitis,there were no statistical differences between the treated group and the control group(P>0.05).Both of the two groups yielded the 1-year survival rate of 94.90%,there was no statistical difference.The treated group yielded a higer 2-year survival rate of 83.40%,compared to the control group of 66.00%.The treated group yielded a higer 3-year survival rate of 77.70%,compared to the control group of 54.00%.In comparison of 2-and 3-year survival rates there was statistical difference between the two groups(P<0.05).Conclusion Applying fluorouracil sustained release in radical operation for gastrointestinal carcinoma can improve the survival rate,which is a kind of effective intraperitoneal chemotherapy with slightly toxic reaction and side effect.