| EB病毒基因甲基化与肿瘤的关系 |
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| 引用本文： | 路素丽. EB病毒基因甲基化与肿瘤的关系[J]. 医学综述, 2011, 17(6): 838-841 |
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| 作者姓名： | 路素丽 |
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| 作者单位： | 南华大学肿瘤研究所,湖南,衡阳,421001 |
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| 摘 要： | EB病毒(EBV)中DNA甲基化导致了基因组的不稳定,对肿瘤发生起着重要作用。EBV启动子的失活主要是由于启动子被甲基化,EBV基因的高甲基化状态有助于其逃避免疫系统的监视作用,并长期存在于宿主细胞内。推测EBV可能通过表观遗传机制调控病毒基因启动子,尤其是通过EBV基因甲基化状态来调控病毒基因的表达,从而导致肿瘤的发生。EBV甲基化与多种肿瘤的发生发展密切相关,在此对EBV基因甲基化与肿瘤的关系进行简要综述。
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| 关 键 词： | EB病毒 甲基化 肿瘤 |
The Relationship between EBV Gene Methylation and Tumorigenesis |
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| LU Su-li. The Relationship between EBV Gene Methylation and Tumorigenesis[J]. Medical Recapitulate, 2011, 17(6): 838-841 |
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| Authors: | LU Su-li |
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| Affiliation: | LU Su-li,GAN Run-liang.(Cancer Research Institute,University of South China,Hengyang 421001,China) |
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| Abstract: | EB virus(EBV) DNA methylation leads to genomic instability and plays an important role in tumorigenesis.EBV promoter is inactivated mainly due to the methylation of promoter.EBV gene hypermethylation helps EBV to escape from immune monitoring and persist in host cells.The speculation that EBV controls viral gene promoter through epigenetic mechanisms,in particular through the methylation of EBV genes to regulate expression of viral genes,thus,leads to tumorigenesis.The occurrence of EBV methylation is close... |
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| Keywords: | EB virus Methylation Tumor |
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