Visfatin与代谢综合征及运动的研究进展

随着众多脂肪细胞因子,如瘦素、抵抗素、网膜素以及内脂素等的发现,长期以来被认为是能量贮备的脂肪组织,其内分泌功能亦逐渐被人们所认识。Visfatin是新近发现的由内脏脂肪细胞分泌的一种脂肪因子,与前B细胞集落增强因子结构相同,具有胰岛素样作用、能促进脂肪的积聚和合成、参与动脉粥样硬化的形成、调节血管平滑肌的成熟,并受多种因素调控,它可能是与肥胖、糖尿病等代谢综合征相关的蛋白。现主要探讨Visfatin与代谢综合征及运动的研究进展,拓宽研究药物治疗及运动治疗代谢综合征的思路。

Research Progress in the Relationship between Visfatin,Metabolic Syndrome and Exercise

Adipose tissue has always been regarded as an organ for energy storage,but since the discovery of adipokines such us leptin,resistin,omentin and Visfatin,its function as an endocrine organ was confermed.Visfatin is a newly discovered adipocytokine synthesized mainly by visceral fat.Its structure is the same as pre-B-cell cloning-enhancing factor.Visfatin can imitate insulin actions,facilitate accumulation and synthesis of adipose tissue,participate in atherosclerosis,and modulate maturation of vascular smmo...