| 卡马西平诱发药疹与HLA-B在汉族人群中的关系 |
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| 引用本文： | 曹志豪. 卡马西平诱发药疹与HLA-B在汉族人群中的关系[J]. 医学综述, 2011, 17(6): 923-925 |
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| 作者姓名： | 曹志豪 |
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| 作者单位： | 复旦大学附属华山医院皮肤科,上海,200040 |
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| 摘 要： | Stevens-Johnson综合征(SJS)和中毒性表皮坏死松解症(TEN)是一类发病率低却可危及生命的皮肤不良反应,卡马西平(CBZ)是常见诱发药物之一。近年来许多地区报道HLA-B*1502与CBZ在汉族人群中诱发SJS和TEN强相关,而在高加索人种中却没有类似发现,存在种族差异。目前CBZ仍然是临床中常用药物。现对CBZ诱发SJS和TEN与HLA-B*1502在汉族人群的关系进行综述,为临床用药安全性提供参考。
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| 关 键 词： | Stevens-Johnson综合征 中毒性表皮坏死松解症 HLA-B*1502 汉族 药疹 |
Carbamazepine-induced Drug Eruption of Epidermolysis Bullosa Associated with HLA-B*1502 Allele in Han Chinese |
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| CAO Zhi-hao. Carbamazepine-induced Drug Eruption of Epidermolysis Bullosa Associated with HLA-B*1502 Allele in Han Chinese[J]. Medical Recapitulate, 2011, 17(6): 923-925 |
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| Authors: | CAO Zhi-hao |
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| Affiliation: | CAO Zhi-hao1,LUO Xiao-qun2.(Department of Dermatology,Huashan Hospital Affiliated to Fudan University,Shanhai 200040,China) |
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| Abstract: | Stevens-Johnson syndrome(SJS)and toxic epidermal necrolysis(TEN)are rare but life-threatening severe cutaneou adverse reactions.One of the drugs most frequently associated with SJS/TEN is cabamazepine.Recently,strong association between HLA-B*1502 and carbamazepine-indeced SJS and TEN have been found in Chinese Han population,but not in Caucasian.Ethinicity might be a risk factor.Carbamazepine is prescribed in clinical work currently,the objective of this study is to review accociation HLA-B*1502 with carba... |
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| Keywords: | HLA-B*1502 |
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