| 基质金属蛋白酶及抑制剂与急性肺损伤/呼吸窘迫综合征 |
| |
| 引用本文： | 赵鸿飞,滕林. 基质金属蛋白酶及抑制剂与急性肺损伤/呼吸窘迫综合征[J]. 医学综述, 2011, 17(6): 817-819 |
| |
| 作者姓名： | 赵鸿飞 滕林 |
| |
| 作者单位： | 1. 三峡大学人民医院,宜昌市第一人民医院肾内科,湖北,宜昌,443000
2. 上海交通大学医学院,上海,200240 |
| |
| 摘 要： | 基质金属蛋白酶(MMPs)及其抑制剂在急性肺损伤(ALI)和急性呼吸窘迫综合征(ARDS)中的比例平衡决定细胞外基质是否处于平衡,起着调节血管内皮通透性、吸引炎性细胞迁移、维持炎症持续等重要作用。但目前对于MMPs及其抑制物如何相互精细协调,它们在发病过程中是否牵涉其他作用目前还不是很清楚。对MMPs及其抑制剂与ALI/ARDS关系的进一步深入研究,可以为早期诊断和防治ALI/ARDS开辟新的途径。
|
| 关 键 词： | 基质金属蛋白酶 基质金属蛋白酶抑制剂 急性肺损伤 急性呼吸窘迫综合征 |
Matrix Metalloproteinases and Inhibitors in Acute Lung Injury/Acute Respiratory Distress Syndrome |
| |
| ZHAO Hong-fei,TENG Lin. Matrix Metalloproteinases and Inhibitors in Acute Lung Injury/Acute Respiratory Distress Syndrome[J]. Medical Recapitulate, 2011, 17(6): 817-819 |
| |
| Authors: | ZHAO Hong-fei TENG Lin |
| |
| Affiliation: | ZHAO Hong-fei1,TENG Lin2,LIU Xian-zhe3.(1.Department of Nephrology,the People's Hospital of Three Gorge University,the First Peoples Hospital of Yichang,Yichang 443000,China,2.Shanghai Jiao Tong University School of Medicine,Shanghai 200025,3.People's Hospital of Three Gorge University,China) |
| |
| Abstract: | The ratio of matrix metalloproteinase(MMPs) and their inhibitors determines the balance of synthesis and degradation of extracellular matrix(ECM) in acute lung injury(ALI) and acute respiratory distress syndrome(ARDS).They play an important and distinct part in ALI and ARDS.Present studies indicate that MMPs and their inhibitors play a very important role in microvascular permeability,inflammatory cell migration,and inflammatory response in the pathogenesis in ALI and ARDS.Therefore,further research on the ... |
| |
| Keywords: | Matrix metalloproteinase Matrix metalloproteinase inhibitor Acute lung injury Acute respiratory distress syndrome |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
