| 雷公藤甲素抑制胰腺癌的研究进展 |
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| 引用本文： | 徐秀利.雷公藤甲素抑制胰腺癌的研究进展[J].医学综述,2011,17(7):996-998. |
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| 作者姓名： | 徐秀利 |
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| 作者单位： | 福建医科大学附属第二医院肝胆胰外科,福建,泉州,362000 |
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| 基金项目： | 福建省自然科学基金，福建医科大学2009年校重大科研资助项目 |
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| 摘 要： | 雷公藤甲素(TPL)是从雷公藤植物中提取的环氧二萜类化合物。TPL对胰腺癌体外培养细胞及体内实体瘤细胞均有明显的生长抑制作用,主要通过诱导细胞凋亡或促进细胞自溶这两种不同方式杀伤各种类型的胰腺癌细胞。TPL诱导胰腺癌细胞凋亡的主要作用机制有下调部分原癌基因,抑制热休克蛋白70,活化caspase以及抑制核因子κB的激活。此外,TPL还能增强肿瘤细胞对放化疗的敏感性。
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| 关 键 词： | 雷公藤甲素 凋亡 自溶 胰腺癌 |
Research Progress in the Inhibitory Effect of Triptolide on Pancreatic Cancer |
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| XU Xiu-li.Research Progress in the Inhibitory Effect of Triptolide on Pancreatic Cancer[J].Medical Recapitulate,2011,17(7):996-998. |
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| Authors: | XU Xiu-li |
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| Institution: | XU Xiu-li,LI Xin-feng,WANG Wei.(Department of Hepatobiliary and Pancreatic Surgery,the Second Affiliated Hospital of Fujian Medical University,Quanzhou 362000,China) |
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| Abstract: | Triptolide(TPL) is a diterpenoid originally isolated from Tripterygium Hook wilfordii.It has been reported that triptolide inhibits the growth of pancreatic cancer cells in vitro and suppresses tumor growth in vivo.TPL kills diverse types of pancreatic cancer cells by inducing apoptosis or promoting cell autolysis.The mechanisms by which triptolide induces apoptosis of pancreatic cancer cells include the down-regulation of some oncogenes,inhibition of heat shock protein 70,activation of caspase,and inhibiti... |
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| Keywords: | Triptolide Apoptosis Autophagy Pancreatic cancer |
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