益赛普治疗强直性脊柱炎的观察和护理

目的：观察益赛普治疗强直性脊柱炎的疗效及不良反应，并探讨护理策略。方法：对22例强直性脊柱炎应用益赛普治疗，分别在0、6、12周评价临床疗效及不良反应，并探讨早期护理干预措施。结果：患者治疗后BAS—DAI、脊柱痛、胸廓扩张度、Schober、脊柱侧弯、踝间距及CRP、ESR等指标在第6、12周时较治疗前均明显改善，差异均有统计学意义（均P〈0．05）。22例患者12周内共注射益赛普针396次，6例发生不良反应，其中，5例注射部位局部皮肤出现红肿和硬结伴发痒，1例发热。经早期护理措施干预后无一例因不良反应而终止治疗。结论：益赛普治疗活动性强直性脊柱炎疗效显著，能改善强直性脊柱炎患者的症状、体征、关节功能和生活质量。应用益赛普治疗强直性脊柱炎后注射部位皮肤反应较常见，在适当的护理干预下可减少不良反应的发生和不良反应带来的不适。

Clinical observation and nursing on Etanercept in the treatment of ankylosing spondylitis

Objective:To observe the efficacy,adverse reaction and nursing intervention of Etanercept in patients with ankylosing spondylitis.Methods: 22 patients with active ankylosing spondylitis were treated with Etanercept.During the course of treatment,all subjects were assessed at week 0,6,12 respectively.Results: The BASDAI,rachialgia,thoracic expansion,Schober,scoliolosis,intermalleolar distance,CRP,ESR and other indexes at 6 and 12 weeks after treatment were significantly improved compared with those before tr...