环氧化酶2与肝癌的研究进展

环氧化酶(COX)2作为体内前列腺素生物合成的限速酶,是催化花生四烯酸转化为前列腺素的关键酶,COX至少存在两种同工酶:COX-1(结构型)和COX-2(诱导型),近年来还发现有COX-3,但还存在争议。肝癌是我国位居第二的恶性肿瘤,病死率高,预后差。目前研究表明,大多数恶性肿瘤的发生与某些特定基因的改变密切相关。现主要就COX-2在肝癌中的研究进展予以综述。

Recent Advances in COX-2 and Hepatocellular Carcinoma

Cyclooxygenase-2(COX-2) is an inducible key enzyme of arachidonic acid metabolism and a central mediator in inflammation and cancer.Hepatocellular carcinoma(HCC),with a high mortality and poor prognosis,is the second most common malignancy in our country.At present,studies indicate that the occurrence of most malignant tumors is closely correlated with the alterations in some specific genes.This review briefly summarizes the advances of COX-2 and HCC in recent years.