| 快速老化型小鼠SAMP8在阿尔茨海默病研究中的应用 |
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| 引用本文： | 董靖德. 快速老化型小鼠SAMP8在阿尔茨海默病研究中的应用[J]. 医学综述, 2011, 17(6): 804-806 |
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| 作者姓名： | 董靖德 |
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| 作者单位： | 南京医科大学附属脑科医院老年神经科,南京,210029 |
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| 基金项目： | 江苏省自然科学基金(基础研究计划项目)，南京医科大学科技发展基金重点项目 |
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| 摘 要： | 作为衰老模型,SAMP8小鼠显示了许多发生在阿尔茨海默病早期的特性,如行为紊乱、记忆力下降、氧化应激反应增加、β淀粉样蛋白沉积和tau蛋白磷酸化。因此,SAMP8小鼠是研究早期阿尔茨海默病的极佳模型。通过回顾SAMP8小鼠的行为学、神经化学及神经病理特性,研究SAMP8小鼠在阿尔茨海默病发病机制中的价值。
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| 关 键 词： | SAMP8小鼠 阿尔茨海默病 氧化应激 发病机制 |
Progress in Accelerated Senescence Animal Models of SAMP8 Mice for Studying Alzheimer Disease |
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| DONG Jing-de. Progress in Accelerated Senescence Animal Models of SAMP8 Mice for Studying Alzheimer Disease[J]. Medical Recapitulate, 2011, 17(6): 804-806 |
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| Authors: | DONG Jing-de |
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| Affiliation: | DONG Jing-de,WANG Xiao-shan.(Department of Geriatric Neurology,the Brain Hospital Affiliated Nanjing Medical University,Nanjing 210029,China) |
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| Abstract: | As the aging model,SAMP8 mice showed many features occurred in the early of Alzheimer disease,such as behavior disorders,memory impaired,oxidative stress increased,β-amyloid deposition and tau protein phosphorylation.Therefore SAMP8 mice was an excellent model for study of early AD.The paper discussed the value of this model about the pathogenesis of Alzheimer′s disease by reviewing behavioral,neurochemical and neuropathological characteristics of SAMP8 mice. |
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| Keywords: | Senescence accelerated mouse prone 8 Alzheimer disease Oxidative stress Pathogenesis |
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