| 肝细胞生长因子与肝纤维化关系研究进展 |
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| 引用本文： | 黄莹莹.肝细胞生长因子与肝纤维化关系研究进展[J].医学综述,2011,17(6):825-827. |
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| 作者姓名： | 黄莹莹 |
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| 作者单位： | 复旦大学附属中山医院消化科,上海,200032 |
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| 摘 要： | 肝细胞生长因子是一种多效性的细胞因子,具有促细胞分裂、增殖、运动、抗纤维化等多种生物学活性。它可以通过抑制减少转化生长因子β1合成和信号转导、减少肝星形细胞活化和增殖、抑制胶原纤维合成、促进细胞外基质降解、抑制上皮-间质转化等多种机制来发挥抗肝纤维化效应,具有开发成为一种有效的抗纤维化临床药物的巨大潜能。
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| 关 键 词： | 肝细胞生长因子 肝纤维化 肝星形细胞 |
Recent Progress in the Association between Hepatocyte Growth Factor and Liver Fibrosis |
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| HUANG Ying-ying.Recent Progress in the Association between Hepatocyte Growth Factor and Liver Fibrosis[J].Medical Recapitulate,2011,17(6):825-827. |
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| Authors: | HUANG Ying-ying |
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| Institution: | HUANG Ying-ying,SUN Jian-yong.(Department of Gastroenterology,Zhongshan Hospital Affiliated to Fudan University,Shanghai 200032,China) |
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| Abstract: | Hepatocyte growth factor(HGF) is a multifunctional cytokine,which acts as a potent mitogen for mature hepatocytes and promoter for liver regeneration after liver injury.HGF can ameliorate liver fibrosis through multiple mechanisms,including decreasing the expression and signal transduction of transforming growth factor-beta 1,inhibiting the proliferation and activation of hepatic stellate cell,reducing the synthesis of collagen,promoting the degradation of extracellular matrix,and modulating the epithelial-... |
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| Keywords: | Hepatocyte growth factor Liver fibrosis Hepatic stellate cell |
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