| 鲍曼不动杆菌16SrRNA甲基化酶的研究进展 |
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| 引用本文： | 张利娟. 鲍曼不动杆菌16SrRNA甲基化酶的研究进展[J]. 医学综述, 2011, 17(5): 676-678 |
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| 作者姓名： | 张利娟 |
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| 作者单位： | 天津医科大学研究生院,天津,300070 |
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| 摘 要： | 氨基糖苷类抗菌药在治疗严重细菌感染,尤其是革兰阴性杆菌感染中发挥着重要的作用。鲍曼不动杆菌16SrRNA甲基化酶是近年来发现的一种新的耐药决定因子,介导对多种氨基糖苷类高水平耐药。目前在革兰阴性菌中已发现7种16SrRNA甲基化酶基因(armA、rmtA、rmtB、rmtC、rmtD、rmtE和npmA),鲍曼不动杆菌中仅发现armA。此类基因常位于质粒、Ⅰ类整合子或转座子上,引起耐药机制的传播。
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| 关 键 词： | 鲍曼不动杆菌 氨基糖苷类 16SrRNA甲基化酶 armA |
Research Progress on 16SrRNA Methylases of Acinetobacter Baumannii |
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| ZHANG Li-juan. Research Progress on 16SrRNA Methylases of Acinetobacter Baumannii[J]. Medical Recapitulate, 2011, 17(5): 676-678 |
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| Authors: | ZHANG Li-juan |
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| Affiliation: | 1.Graduate School of Tianjin Medical University,Tianjin 300070,China;2.Department of Infectious Control,Affiliated Hospital,Medical College of Chinese People′s Armed Police Forces,Tianjin 300162,China) |
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| Abstract: | Aminoglycoside has played an important role on the treatment of life-threatening infections especially caused by Gram-negative bacilli bacterias.Recently,16SrRNA methylases in Acinetobacter baumannii,a novel aminoglycoside resistance determinant factor,confering a high level of resistance to various clinically important aminoglycosides has been discovered.At present,seven types of 16SrRNA methylases genes(armA,rmtA,rmtB,rmtC,rmtD,rmtE and npmA)has been found in members of the family gram-negative bacilli,wh... |
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| Keywords: | armA |
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