| 清肝利胆口服液对酒精性肝损伤的保护作用 |
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| 引用本文： | 王珏,周可军.清肝利胆口服液对酒精性肝损伤的保护作用[J].中国医药导报,2011,8(3):54-55. |
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| 作者姓名： | 王珏 周可军 |
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| 作者单位： | 1. 河南信心药业有限公司,河南郑州,450052
2. 河北中医肝病医院,河北石家庄,050800 |
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| 摘 要： | 目的：研究清肝利胆口服液对酒精性肝损伤的保护作用。方法：采用白酒制备大鼠酒精性肝损伤模型，清肝利胆口服液按高、低剂量灌胃。连续8周，测定血清天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）的含量，检测肝组织丙二醛（MDA）及还原型谷胱甘肽（GSH）的含量，并观察肝脏的病理组织学改变。结果：清肝利胆口服液组可显著降低大鼠血清AST、ALT含量。与肝损模型组比较，差异有统计学意义（P〈0．01或P〈0．05）；受试样品高、低剂量组大鼠肝组织的MDA含量均值均低于肝损模型组；GSH含量均高于肝损模型组；肝组织病理学改变较肝损模型组显著减轻。结论：清肝利胆口服液对大鼠酒精性肝损伤具有保护作用，呈一定的量效关系。
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| 关 键 词： | 清肼利胆口服液 酒精性肝损伤 肝组织 保护作用 |
The protective effect of Qingganlidan Oral Liquid in alcoholic liver injury |
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| WANG Jue,ZHOU Kejun.The protective effect of Qingganlidan Oral Liquid in alcoholic liver injury[J].China Medical Herald,2011,8(3):54-55. |
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| Authors: | WANG Jue ZHOU Kejun |
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| Institution: | 1.He′nan Confidence Pharmaceutical Co.Ltd.,Zhengzhou 450052,China;2.Hebei Hepatopathy Hospital of TCM,Shijiangzhuang 050800,China) |
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| Abstract: | Objective: To study the protective effect of Qingganlidan Oral Liquid on alcoholic liver injury.Methods: The alcoholic liver injury model of rat was established by adopting alcohol,was administered intragastrically with Qingganlidan Oral Liquid of high-dose and low-dose respectively for 8 weeks,the serum content of AST,ALT,the liver content of MDA and GSH were measured,the liver histopathological changes were observed.Results: Qingganlidan Oral Liquid could significantly lower the serum content of AST,ALT,a... |
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| Keywords: | Qingganlidan Oral Liquid Alcoholic liver injury Liver tissue Protective effect |
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