| 脑缺血/再灌注损伤后内质网应激对神经元转归的影响 |
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| 引用本文： | 赵鹏.脑缺血/再灌注损伤后内质网应激对神经元转归的影响[J].医学综述,2011,17(5):679-682. |
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| 作者姓名： | 赵鹏 |
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| 作者单位： | 解放军第三军医大学第二附属医院急救部,重庆,400037;解放军65316部队医院普外科,长春,130051 |
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| 摘 要： | 内质网本身在细胞生理及组成结构方面起至关重要的作用,当内质网出现功能障碍时,未折叠蛋白反应(UPR)试图增加未折叠蛋白的折叠能力而减轻内质网应激(ERS)的压力。当无法缓解时,细胞便通过内质网凋亡途径走向凋亡。而脑缺血/再灌注损伤(CIRI)会导致内环境紊乱,引起ERS反应,进而通过ERS途径引起神经元凋亡。现对内质网的结构、功能、ERS机制、ERS后产生的UPR机制以及凋亡机制予以阐述,并提出了对CIRI后ERS状态下神经元转归的应对措施。
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| 关 键 词： | 内质网应激 未折叠蛋白反应 脑缺血/再灌注损伤 凋亡 |
Effects of Endoplasmic Reticulum Stress on Outcomes of Neurons following Cerebral Ischemia Reperfusion Injury |
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| ZHAO Peng.Effects of Endoplasmic Reticulum Stress on Outcomes of Neurons following Cerebral Ischemia Reperfusion Injury[J].Medical Recapitulate,2011,17(5):679-682. |
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| Authors: | ZHAO Peng |
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| Institution: | ZHAO Peng1,2,SHI Zhong1.(1.Department of Emergency Medicine,the Second Affiliated Hospital of PLA Third Military Medical University,Chongqing 400037,China,2.Department of General Surgery,PLA 65316 Hospital,Changchun 130051,China) |
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| Abstract: | Endoplasmic reticulum plays a crucial role in cellular physiology and structure.In the presence of endoplasmic reticulum dysfunction,unfoled protein response(UPR)tends to enhance its disposing capacity to alleviate the endoplasmic reticulum stress(ERS).In the case of no response,cells initiate apoptosis through the endoplasmic reticulum apoptosis pathway.Cerebral ischemia-reperfusion injury(CIRI)may lead to the disturbance in internal environment and ERS,further resulting in neuronal apoptosis through the E... |
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| Keywords: | Endoplasmic reticulum stress Unfolded protein response Cerebral ischemia reperfusion injury Apoptosis |
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