| MicroRNA let-7与肿瘤关系的研究进展 |
| |
| 引用本文： | 陈方园.MicroRNA let-7与肿瘤关系的研究进展[J].医学综述,2011,17(12):1797-1800. |
| |
| 作者姓名： | 陈方园 |
| |
| 作者单位： | 浙江中医药大学,杭州,310004;中国人民解放军第117医院呼吸内科,杭州,310004 |
| |
| 摘 要： | microRNA(miRNA)是一种长度约为22 nt的非编码的单链小分子RNA,作用广泛,与肿瘤的发生、发展密切相关。miRNA let-7是最早发现的miRNA之一,是线虫时序性发育的关键性调控因子,在哺乳动物中调节多种细胞的增殖、分化和凋亡,而且在正常组织和肿瘤组织中的表达显著不同,并参与肿瘤的发生、发展。现主要讨论let-7在肿瘤方面的研究进展。
|
| 关 键 词： | microRNA let-7 表达调控 |
Research Progress in the Correlation between MicroRNA let-7 and Cancer |
| |
| CHEN Fang-yuan.Research Progress in the Correlation between MicroRNA let-7 and Cancer[J].Medical Recapitulate,2011,17(12):1797-1800. |
| |
| Authors: | CHEN Fang-yuan |
| |
| Institution: | CHEN Fang-yuan1,2,CHEN Qing-yong2.(1.Traditional Chinese Medicine University of Zhejiang,Hangzhou 310004,China,2.Department of Pulmonary Disease,PLA 117th Hospital,China) |
| |
| Abstract: | microRNA(miRNA)are a group of small noncoding functional RNAs,approximately 22 nt in length with extensive function,closely related to cancer development and progression.miRNA let-7 was firstly discovered in the nematode caenorhabditis elegans,where it regulates the timing of stem-cell proliferation and differentiation.let-7 miRNA seems to play a critical role in cell proliferation,differentiation and apoptosis in mammals,with significant expression difference in the normal tissue and tumor tissue,where it ... |
| |
| Keywords: | microRNA let-7 |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
