| 糖尿病和非糖尿病人群的CYP2C9基因多态性分析 |
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| 引用本文： | 陈广原,余湘文,石永英,邓雪峰. 糖尿病和非糖尿病人群的CYP2C9基因多态性分析[J]. 中国医药导报, 2011, 8(2): 20-22 |
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| 作者姓名： | 陈广原 余湘文 石永英 邓雪峰 |
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| 作者单位： | 广州医学院第一附属医院老年科,广东广州,510120 |
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| 摘 要： | 目的：探索糖尿病患者和非糖尿病人群肝药酶细胞色素P450（CYP2C9）基因多态性。方法：对入选的研究对象使用CYP2C9基因分型实时荧光PCR试剂盒进行CYP2C9基因多态性检测。结果：本研究糖尿病患者380例,CYP2C9﹡1/﹡3基因型频率为4.21%;非糖尿病人群208例,CYP2C9﹡1/﹡3基因型频率为5.77%。糖尿病患者与非糖尿病人群比较,CYP2C9基因多态性分布差异无统计学意义。结论：糖尿病患者与非糖尿病人群均存在CYP2C9基因多态性,检测患者CYP2C9基因分型可提供用药参考。
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| 关 键 词： | 糖尿病 肝药酶细胞色素P450（CYP2C9） 基因多态性 |
The analysis about gene polymorphism of CYP2C9 in diabetic patients and non-diabetic population |
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| CHEN Guangyuan,YU Xiangwen,SHI Yongying,DENG Xuefeng. The analysis about gene polymorphism of CYP2C9 in diabetic patients and non-diabetic population[J]. China Medical Herald, 2011, 8(2): 20-22 |
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| Authors: | CHEN Guangyuan YU Xiangwen SHI Yongying DENG Xuefeng |
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| Affiliation: | CHEN Guangyuan,YU Xiangwen,SHI Yongying,DENG Xuefeng(Department of Geriatrics,the First Affiliated Hospital of Guangzhou Medical College,Guangzhou 510120,China) |
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| Abstract: | Objective: To investigate the cytochrome P450(CYP2C9) gene polymorphism of diabetic patients and non-diabetic population.Methods: CYP2C9 gene polymorphism was detected by real-time PCR in objects.Results: 380 cases of diabetes were studied in this research,the CYP2C9*1/*3 genotype frequency was 4.21%.208 cases of non-diabetic population were studied,the CYP2C9*1/*3 genotype frequency was 5.77%.No significant difference was observed in the frequencies between diabetic patients and non-diabetic population.Con... |
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| Keywords: | Diabetes Cytochrome P450(CYP2C9) gene polymorphism |
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