非酒精性脂肪肝的危险因素及脂肪肝诊断的研究进展

脂肪肝是常见病,可以发展成肝硬化,原发性肝癌等严重疾病。其中以非酒精性脂肪肝(NAFLD)发病更为复杂,该病与促炎性因子增加、脂质代谢紊乱、动脉粥样硬化、高血压病、2型糖尿病和代谢综合征等密切相关,其中胰岛素抵抗、肥胖、脂代谢紊乱、热量(特别是脂肪过度摄入)是诱发NAFLD的重要因素。肝组织细胞活检是确诊脂肪肝最直接、准确的手段,但因条件限制,B超、CT及3.0 T磁共振氢波谱成像都成为诊断脂肪肝的手段。

Progress in Research of the Risk Factors of Nonalcoholic Fatty Liver and Diagnosis of Fatty Liver

Fatty liver is a common disease,which may develop into serious diseases such as cirrhosis and primary liver cancer.Among them,the nonalcoholic fatty liver disease(NAFLD)is more complex,which is closely related to the inflammatory factor increase,lipid metabolism disorders,atherosclerosis,hypertension,type Ⅱ diabetes and metabolic syndrome.Insulin resistance,obesity,lipid metabolism disorders,and heat(especially fat) excessive intaking are all important predisposing factors of NAFLD.Liver tissue cell biopsy is the most direct and accurate diagnosis of fatty liver,however,due to the condition limitation,B ultrasonic,CT and 3.0 T magnetic resonance hydrogen spectrum imaging are all adopted for the diagnosis.