肺动脉高压相关标记物研究进展

近年来，随着对肺动脉高压发病机制的进一步认识，肺动脉高压的诊断和治疗有了很大进步。靶向药物的使用在一定程度上改善了肺动脉高压患者的病情发展，但肺动脉高压的远期预后仍不容乐观。因此，寻找能监测病情严重程度、预后及患者对治疗反应的可靠指标显得至关重要。目前国内外有不少研究致力于寻找非侵入性的、能客观评价病情严重程度及预后的生物标记物。本文针对研究发现的部分标记物作一简要综述。

Research progress in the biomarkers of pulmonary arterial hypertension

In recent years, with the further understanding of the pathogenesis of pulmonaryarterial hypertension, great progress in the diagnosis and treatment of pulmonary arterial hypertension has been made. hTe use of targeted drugs to a certain extent improves the illness development of patients with pulmonary arterial hypertension, but the long-term prognosis of the disease is still not optimistic. Therefore, seeking reliable biomarkers which can monitor disease severity, prognosis and the response to treatment in patients seems crucial. hTere are a number of researches at home and abroad looking for non-invasive biomarkers which can objectively evaluate theseverity and prognosis of the disease. In this paper part of the biomarkers are brielfy reviewed.