高尿酸血症与非酒精性脂肪性肝病

非酒精性脂肪性肝病是由于肝脏中脂肪过度沉积,诱发炎性反应以及氧化应激损伤的一组疾病.而尿酸是人类嘌呤代谢的终产物,在体内起到抗氧化、调节免疫功能等生理作用.越来越多的证据表明高尿酸血症与非酒精性脂肪性肝病有关.不论是横断面研究还是前瞻性研究均显示高尿酸血症是非酒精性脂肪性肝病的独立危险因素.高尿酸血症可成为机体的致炎因子,诱导胰岛素抵抗,激发炎性反应信号通路,诱导炎性因子的产生,导致肝细胞中脂肪的积聚和炎性损伤.降尿酸治疗可对肝脏起到保护作用,可能成为非酒精性脂肪性肝病的治疗手段.

Hyperuricemia and non-alcoholic fatty liver

Non-alcoholic fatty liver disease (NAFLD) is a state of intrahepatic fat accumulation,which induces inflammatory reaction and oxidative stress.Uric acid is the end product of endogenous purines degration,which can play antioxidant role and regulate immunity.A growing number of evidence indicates that hyperuricemia is associated with NAFLD.Both cross-sectional and prospective studies indicated that hyperuricemia was the risk factor of NAFLD.Hyperuricemia can become proinflammatory factors,inducing insulin resistance,stimulating infammatory signal pathway,and leading to fatty accumulation in the liver.Hypouricemia therapy plays protective role in the liver,and may become a therapeutic target of NAFLD.