| 输血相关急性肺损伤及其预防与控制策略的研究进展 |
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| 引用本文： | 钟周琳,周燕,李丽兰,申卫东.输血相关急性肺损伤及其预防与控制策略的研究进展[J].国际输血及血液学杂志,2016(1):81-84. |
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| 作者姓名： | 钟周琳 周燕 李丽兰 申卫东 |
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| 作者单位： | 南宁输血医学研究所, 南宁中心血站,530003 |
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| 基金项目： | Natural Science Foundation of Guangxi Zhuang Autonomous Region(2013GXNSFBA019206)，Scientific Research and Technology Development Project of Nanning City(20133141)，广西壮族自治区自然科学基金项目(2013GXNSFBA019206)，南宁市科学研究与技术开发计划项目(科技惠民重大科技专项)(20133141) |
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| 摘 要： | 输血相关急性肺损伤(TRALI)是指输血后6h内发生的急性肺损伤(ALI),是输血导致患者死亡的主要原因之一.目前对TRALI发病机制的假说包括“二次打击”学说与“阈值模型”学说等.超过80％ TRALI是由输注的血液制品中含特异性抗人类白细胞抗原(HLA)或人类中性粒细胞抗原(HNA)抗体介导的,并且导致TRALI发生的血液制品,主要来源于有多次妊娠史的女性献血者.目前,多个国家实行以男性献血者为主体,供应高血浆含量血液制品的临床预防、控制TRALI策略,以效降低TRALI发生率.笔者拟就TRALI的定义、发病机制、诊断、预防控制策略进行综述.
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| 关 键 词： | 输血相关性急性肺损伤 发病机制 预防控制策略 |
Research progress of transfusion related acute lung injury and its prevention and control strategies |
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| Abstract: | Transfusion-related acute lung injury (TRALI) which occurs acute lung injury (ALI) within 6 hours after transfusion is one of the leading causes of death in patients with blood transfusion.Several hypothesises have been proposed to explain the underlying pathologic mechanisms of TRALI,such as "two-event" and "threshold model" hypothesis,etc..Immune-mediated TRALI accounts for over 80％ of reported cases of TRALI which was mediated by HLA (human leucocyte antigen) or human neutrophil antigens (HNA) antibodies in transfused blood products.Immune-mediated TRALI is commonly associated with donor plasma transfusion or other blood products from multiparous women,which has led many countries to reduce or exclude women from donating high-volume plasma products.This policy has resulted in a decrease in the incidence of TRALI.This article reviews the definition,pathogenesis,diagnosis,prevention and control strategies of TRALI. |
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| Keywords: | Transfusion related acute lung injury Pathogenesis Mitigation strategies |
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