化瘀镇痛胶囊结合手法治疗腰椎间盘突出症临床研究

目的 探讨化瘀镇痛胶囊结合中医手法对腰椎间盘突出症(lumbar intervertebral disc herniation,LIDH)患者炎性细胞因子表达水平的影响,评价其临床疗效.方法 将符合入选标准的LIDH患者80例,按随机数字表法分为2组.全部患者均施以手法治疗.对照组在此基础上加服洛索洛芬钠分散片,观察组在此基础上加服化瘀镇痛胶囊.7d为1个疗程,均连续治疗2个疗程.分别于治疗前后,采用流式细胞法检测IL-6和IL-8水平;采用视觉模拟量表(Visual Analogue Scale,VAS)评价患者疼痛程度;采用Oswestry功能障碍指数(Oswestry Disability Index,ODI)评价患者的功能障碍程度.结果 治疗后,观察组VAS评分[(2.22±0.31)分比(3.54±0.67)分,t=11.309]及ODI指数[(10.51±3.22)比(15.54±6.21),t=4.548]均较对照组降低(P值均＜0.01).淋巴细胞IL-6[(0.58±0.20)％比(0.84±0.32)％,t=4.358]、IL-8[(0.41±0.11)％比(0.61±0.20)％,t=5.542]水平及单核细胞IL-6[(25.31±4.26)％比(29.19±5.32)％,t=3.604]、IL-8[(17.80±2.81)％比(23.31±3.77)％,t=7.411]水平均较对照组明显降低(P值均＜0.01).观察组总有效率为100.0％ (40/40),对照组为75.0％ (30/40),2组比较差异有统计学意义(x2=9.257,P=0.002).结论 化瘀镇痛胶囊结合中医手法可降低LIDH患者的炎性细胞因子IL-6、IL-8水平,有效缓解局部肌肉痉挛,改善患者的疼痛症状,疗效优于中医手法联用洛索洛芬钠分散片.

Clinical study on Huayu-Zhentong capsule combined with traditional manipulation for after operation of lumbar intervertebral disc herniation

Objective To evaluate the efficacy of Huayu-Zhentong capsule combined with traditional manipulation in patients with inflammatory cytokines after operation of lumbar intervertebral disc herniation.Methods A total of 80 patients with orthopedic inpatients were enrolled and divided into two group by random number table method:a treatment group (40 patients) and a control group (40 patients).On this basis,the control group was added to loxoprofen sodium dispersible tablets,the treatment group was added to Huayu-Zhentong capsule.2 groups were continuous treated for 2 courses.Flow cytometry was used to detect the level of IL-8 and IL-6 before and after treatment,and the patients were evaluated by VAS.The clinical efficacy was evaluated by Oswestry ODI.Results After treatment,the VAS score (2.22 ± 0.31 vs.3.54 ± 0.67,t=11.309) and ODI (10.51 ± 3.22 vs.15.54 ± 6.21,t=4.548) of the treatment group were decreased than the control group (both P＜0.01).Lymphocyte IL-6(0.58％ ± 0.20％ vs.0.84％ ± 0.32％,t=4.358),IL-8(0.41％ ± 0.11％ vs.0.61％ ± 0.20％,t=5.542),mononuclear cells IL-6(25.31％ ± 4.26％ vs.29.19％ ± 5.32％,t=3.604),IL-8(17.80％ ± 2.81％ vs.3.31％ ± 3.77％,t=7.411) of the treatment group were lower than the control group (all P＜0.01).The total effective rate (100％ vs.75.0％) of the treatment group was better than the control group (x2=9.257,P=0.002).Conclusions Huayu-Zhentong capsule combinated with traditional manipulation can reduce inflammatory cytokines IL-6 and IL-8 levels in patients with LIDH.Its curative effect is better than traditional manipulation with loxoprofen sodium dispersible tablets.