中国新疆地区维吾尔族人群缺血性卒中的危险因素

目的：探讨中国新疆维吾尔族人群缺血性卒中的危险因素。方法采用病例对照研究模式，按照民族、性别和年龄进行匹配的原则，对504例首发缺血性卒中维吾尔族患者和507例维吾尔族健康对照者进行调查，筛选缺血性卒中的危险因素。结果多变量logistic回归分析显示，肥胖[优势比（odds ratio, OR）4.82，95％可信区间（confidence interval, CI）1.80~12.94；P=0.002]、高血压（ OR 8.20，95％CI 4.93~13.51；P<0.001）和心脏病（ OR 2.40，95％CI 1.07~5.39；P=0.033）是维吾尔族缺血性卒中的独立危险因素，而初中以上文化程度（ OR ）0.38，95％CI 0.18~0.81；P=0.012）、饮茶习惯（ OR 0.22，95％CI 0.06~0.70；P=0.021）和有午睡习惯（ OR 0.38，95％CI 0.24~0.59；P<0.001）、高水平的高密度脂蛋白胆固醇（ OR 0.34，95％CI 0.20~0.59；P<0.001）和载脂蛋白A（ OR 0.23，95％CI 0.07~0.77；P=0.017）均为缺血性卒中的独立保护因素。结论中国新疆维吾尔族人群缺血性卒中的危险因素较多且典型，调整该民族饮食结构，少进食肉类和高盐饮食，多摄取高纤维食物和鱼类等，并适当加强体育锻炼可能将在维吾尔族人群的卒中预防起着重要的作用。

Risk factors for ischemic stroke in Uygur population in Xinjiang,China

Objective To investigate the risk factors for ischemic stroke in Uygur population in Xinjiang, China. Methods Using a case-control study mode, 504 Uygur patients with first-ever ischemic stroke and 507 Uygur healthy subjects w ere investigated in accordance w ith the principle of the ethnic, sex, and age matching. The risk factors for ischemic stroke w ere screened. Results Multivariate logistic regres-sion analysis showed that the obesity (odds ratio [OR] 4.82, 95% confidence interval [CI] 1.80-12.94;P=0.002), hypertension ( OR 8.20, 95%CI 4.93-13.51; P<0.001), and heart disease ( OR 2.40, 95%CI 1.07-5.39;P=0.033) w ere the independent risk factors for ischemic stroke in Uygurs. While the education level of junior high school or above ( OR 0.38, 95%CI 0.18-0.81;P=0.012), tea drinking habit ( OR 0.22, 95%CI0.06-0.70; P=0.021), siesta habit ( OR 0.38, 95%CI 0.24-0.59; P<0.001), high levels of high-density lipoprotein cholesterol ( OR 0.34, 95%CI 0.20-0.59; P<0.001), and apolipoprotein A ( OR 0.23, 95%CI 0.07-0.77; P=0.017) were the protective factors for ischemic stroke. Conclusions The risk factors for ischemic stroke are more and typical in Uygur population in Xinjiang, China. Adjusting the diet structure of Uygurs, less taking meats and high-salt diet, intaking high fiber foods and fish, and appropriate physical exercise w il play an important role for the prevention of stroke in Uygur population.