螺旋藻来源的γ-亚麻酸甲酯调血脂作用研究

利用从螺旋藻中提取的γ-亚麻酸甲酯(GLAME)，分别制成含GLAME0.25％、0．5％、1％的饲料喂饲正常大鼠和高脂膳食喂养形成的高脂血症大鼠，连续4周，测定血脂、肝脂及血浆和肝脏丙二醛(MDA)含量。结果表明：GLAME能显著降低正常大鼠和高脂血症大鼠血浆TC、TG、LDL—C含量和AI，升高HDL—C含量和HDL—C／TC，能降低正常大鼠和高脂血症大鼠血浆和肝脏MDA舍主及肝胆固醇含量，降低高脂血症大鼠肝指数(肝重/体重)，但对正常大鼠的肝指数无明显影响。

Studies on the hypolipidemic effects of gamma-linolenic acid methyl ester derived from Spirulina maxima

The hyperlipemia model was established by feeding the rats with high fat diet. The hyperlipidemic rats were fed with the diet containing 0.25%,0.5%,1% gamma-linolenic acid methyl ester(GLAME), which was derived from Spirulina maxima for 4 weeks, then the plasma and liver lipid indexes were detected. The results showed that GLAME could significantly decrease levels of plasma total cholesterol(TC), triglycerides(TG), low density lipoprotein cholesterol(LDL-C) , MDA,atherosclerosis index(AI) and liver TC, MDA, and increase levels of high density lipoprotein cholesterol(HDL-C) in both normal and hyperlipidemic rats. GLAME decreased liver index(the ratio of liver weight and body weight) in hyperlipidemic rats, but had no significant effect in normal rats.