60例遗传过敏性皮炎患者外周血淋巴细胞亚群的流式细胞仪检测结果

本文用OKT系列单克隆抗体以流式细胞仪对60例遗传过敏性皮炎(AD)患者(PAD14例、ADR15例、ADI12例及ADRI19例)外周血淋巴细胞亚群进行了检测。结果表明,总患者组T_3~ 、T_8~ 细胞百分比较正常人显著降低,T_4~ /T_8~ 比值升高。在AD分型观察中,ADR、ADI及ADRI等型患者T_8~ 细胞显著降低,T_4~ /T_8~ 比值升高。AD患者血清IgE显著高于正常人,但与T_8~ 细胞低下无相关性。提示T_8~细胞的低下与遗传过敏性背景有关。

Analysis of peripheral blood lymphoc(?)te subsets in patients with atopic dermatitis.

The peripheral blood lymphocyte subsets were determined by using monoclonal antibody and flow cytometer in 60 patients withatopic dermatitis (AD). The results showed that the percentage of T3~ cell and T8~ cell i n all patients with AD were significantly lower than that of normal control and the overall ratio of T4~ /T8~ cells was significantly elevated in AD patients. It wasalso found that the percentage of T4~ /T8~ cel 1 s was si gnificant1y elevated in AD patients. It was also found that the percentage of T8~ cell in AD patients with respiratory allergy and ichthyosis was significantly reduced. The results indicated that the reduction of T8~ cell might contributed to the atopic status of the AD patients.