环氧化酶-2及表皮生长因子受体在非小细胞肺癌组织中的表达及临床意义

目的探讨环氧化酶-2（COX-2）与表皮生长因子受体（EGFR）在非小细胞肺癌（NSCLC）组织中的表达及与肺癌发生发展的关系。方法采用免疫组化（SP）法检测56例NSCLC和20例正常肺组织中COX-2与EGFR表达。结果56例NSCLC组织中，COX-2与EGFR表达阳性率分别为64．2％，67．8％，显著高于正常肺组织（P〈0．01），COX-2与EGFR表达与临床分期、病理分级、组织学分型、淋巴结转移密切相关（P〈0．05），肿瘤分期愈晚，细胞分化越羞，淋巴结转移越高，COX-2与EGFR表达阳性率越高，腺癌中COX-2表达明显高于鳞癌，鳞癌中EGFR表达高于腺癌（P〈0．05）。结论COX-2与EGFR在NSCLC中异常表达说明其在肺癌发生发展中有重要作用．可作为判断NSCLC的生物学行为及估计预后的指标。

Expressions of Cyclooxygenase-2 and epidermal growth factor receptor in non-small cell lung cancer

Objective To study the expressions of cyclooxy genase-2(COX-2)and epidermal growth factor receptor(EGFR)in tumor tissue and explored the effect of COX-2 and EGFR in NSCLC development.Methods The expression of COX-2 and EGFR were detected by immunohistochemical techniquls in 56 cases of NSCLC and in 20 cases of normal lung tissues.Results The expression of COX-2 and EGFR in NSCLC were significantly higher than that in normal lung tissues(P<0.01),the positive expression rate of COX-2 and EGFR were 64.2% and 67.8%(respectively).The expressions of COX-2 and EGFR in NSCLC were associated with clinical stage,histologic grade,tumor pathological type and lymponode metastasis(P<0.05).The expression of COX-2 and EGFR in the stage III and stage IV of NSCLC were significantly higher than those in stage I and stage II of NSCLC.The expressions of COX-2 and EGFR in the worse differentiated NSCLC were significantly higher than those in the well differentiated NSCLC,and Lymponode metastasis in NSCLC were higher than non-lymponod metastasis(P<0.05).The expression of COX-2 in adenocarcinoma cell was obviously higher than that in squmaous cell carcinoma,the expression of EGFR in squmaous cell carcinoma was higher than that in adenocarcinoma cell(P<0.05).The positive correlation was found between COX-2 and EGFR.Conclusion The experiment suggests that COX-2 and EGFR play roles in nocogenesis and progression of NSCLC.So the expression of COX-2 and EGFR seems to be a useful tumor marker for patients with NSCLC and can be used to evaluate the tumor biological behavior and prognosis.