Evidence for an association between the SRD5A2 (type II steroid 5 alpha-reductase) locus and prostate cancer in Italian patients |
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Authors: | Margiotti K Sangiuolo F De Luca A Froio F Pearce C L Ricci-Barbini V Micali F Bonafe M Franceschi C Dallapiccola B Novelli G Reichardt J K |
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Institution: | Dipartimento di Biopatologia e Diagnostica Per Immagini, Sezione di Genetica, Università "Tor Vergata", Via di Tor Vergata 135, 00133 Rome, Italy. |
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Abstract: | We have investigated the contributions of three polymorphic markers in the SRD5A2 gene to prostate cancer in a group of Italian patients. We have genotyped cases and controls for a polymorphic (TA)n dinucleotide repeat and two functional substitutions, A49T and V89L, substituting respectively alanine with threonine at codon 49, and valine to leucine at codon 89. We found a substantially increased but not significant risk associated with the 49T mutation and a reduction of risk for the V89L substitution. In conclusion, we report on preliminary evidence for both increased and decreased risk associated with separate markers at this locus. |
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