中药分子印迹技术对中医药理论的特殊影响

目的:根据分子印迹技术与实验研究现状探讨中药分子印迹现象对中医药基础理论的影响.方法:结合分子印迹理论基本原理,分析中药分子产生印迹现象的物质基础,结合中医药学科基础理论与中药现代化的要求,寻找更直接的中药作用物质基础.结果:与单成分结构相比,中药及复方成分可以相互络合、复合、螯合、包合、中和、自组装、化学反应形成超分子化合物,中药的物质基础是包括了单成分群在内的超分子体的混合物,超分子与分子之间存在印迹现象,因此在进行中药药性、质量控制、炮制、药物制剂制备、药理学研究时,应特别重视中药超分子之间的印迹作用,中药复方配伍能显著性地改变这一作用形式.结论:中药的物质基础是基于单分子群的超分子混合物,超分子与分子群之间按印迹规律形成作用,这是中药复方区别于单分子药物又一显著的地方.

Special influence of molecular imprinting technology on traditional Chinese medicine theories

Objective: To investigate the influence of molecular imprinting phenomena of traditional Chinese medicines (TCMs) on basic theories of TCMs according to current situations of molecular imprinting technology and experimental studies. Method: Fundamental principles of molecular imprinting theory were followed to analyze the material basis for TCM molecules to generate the imprinting phenomena, in order to find other material basis with more direct efficacy in line with the requirements of basic theories and modernization of TCMs. Result: Compared with single-component structures, TCMs and their compound components could create super-molecular compounds through complexation, composition, chelation, inclusion, neutralization, self-assembly and chemical reaction. The material basis of TCMs was super-molecular compounds including single ingredients, and there was an inter-molecule imprinting phenomenon. Therefore, special attention should be paid to inter-super-molecule imprinting actions in studies on TCM property, quality control, processing, drug preparation and pharmacology. The compatibility of TCM compounds could significantly change the action. Conclusion: The material basis of TCMs is super-molecular compounds based on single molecular groups. Super-molecules and molecular groups act rules, which is another difference between TCM compounds and single molecular drugs.