| 槲皮素纳米结构脂质载体的制备及理化性质研究 |
| |
| 引用本文： | 于莲,杨金儒,刘洋,周彤,匡宇明,卢珊珊,张腾元,郭宇.槲皮素纳米结构脂质载体的制备及理化性质研究[J].中国中药杂志,2013,38(8):1151-1155. |
| |
| 作者姓名： | 于莲 杨金儒 刘洋 周彤 匡宇明 卢珊珊 张腾元 郭宇 |
| |
| 作者单位： | 佳木斯大学药学院黑龙江省高校生物药制剂重点实验室,黑龙江佳木斯,154007 |
| |
| 基金项目： | 国家自然科学基金项目(81274101) |
| |
| 摘 要： | 目的:制备槲皮素纳米结构脂质载体(quercetin nanostuctured lipid carriers,QT-NLC),并对其理化性质进行考察.方法:采用乳化-超声分散法制备QT-NLC,正交试验筛选最优处方.透射电镜观察QT-NLC形态,Zeta电位及粒度分析仪测定Zeta电位、粒径及分布,差示扫描量热法(DSC)进行物相分析,离心超滤法测定包封率,透析法测制剂体外释放行为.结果:按优化条件制备的QT-NLC多为类球形粒子,平均粒径(175±25) nm,粒度分布较均匀,Zeta电位(-23±0.3)mV,DSC结果表明药物以非结晶状分散于纳米粒中,包封率(95.43±0.23)％,载药量(2.38±0.24)％,体外2h累积释放32.2％,后期具有明显的缓释特征.结论:乳化-超声分散法适用于QT-NLC的制备,纳米粒子在胶体溶液中分散均匀,稳定性良好.此制备工艺安全、可靠、重现性好.
|
| 关 键 词： | 槲皮素 纳米脂质载体 理化性质 体外释放 |
| 收稿时间： | 2012/11/20 0:00:00 |
Study on preparation of quercetin nanostructured lipid carriers and their physicochemical properties |
| |
| YU Lian,YANG Jin-ru,LIU Yang,ZHOU Tong,KUANG Yu-ming,LU Shan-shan,ZHANG Teng-yuan and GUO Yu.Study on preparation of quercetin nanostructured lipid carriers and their physicochemical properties[J].China Journal of Chinese Materia Medica,2013,38(8):1151-1155. |
| |
| Authors: | YU Lian YANG Jin-ru LIU Yang ZHOU Tong KUANG Yu-ming LU Shan-shan ZHANG Teng-yuan and GUO Yu |
| |
| Institution: | Key Laboratory of Biological Formulations of Colleges in Heilongjiang Province, School of Pharmacy, Jiamusi University, Jiamusi 154007, China;Key Laboratory of Biological Formulations of Colleges in Heilongjiang Province, School of Pharmacy, Jiamusi University, Jiamusi 154007, China;Key Laboratory of Biological Formulations of Colleges in Heilongjiang Province, School of Pharmacy, Jiamusi University, Jiamusi 154007, China;Key Laboratory of Biological Formulations of Colleges in Heilongjiang Province, School of Pharmacy, Jiamusi University, Jiamusi 154007, China;Key Laboratory of Biological Formulations of Colleges in Heilongjiang Province, School of Pharmacy, Jiamusi University, Jiamusi 154007, China;Key Laboratory of Biological Formulations of Colleges in Heilongjiang Province, School of Pharmacy, Jiamusi University, Jiamusi 154007, China;Key Laboratory of Biological Formulations of Colleges in Heilongjiang Province, School of Pharmacy, Jiamusi University, Jiamusi 154007, China;Key Laboratory of Biological Formulations of Colleges in Heilongjiang Province, School of Pharmacy, Jiamusi University, Jiamusi 154007, China |
| |
| Abstract: | |
| |
| Keywords: | quercetin nanostuctured lipid carrier physicochemical property in vitro release |
| 本文献已被 万方数据 等数据库收录！ |
|
