| 丝裂原活化的蛋白激酶通路与吗啡耐受 |
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| 引用本文： | 张颜波,孙保亮,袁慧,杨明峰,牛敬忠,吕国蔚.丝裂原活化的蛋白激酶通路与吗啡耐受[J].基础医学与临床,2010,30(3):325-328. |
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| 作者姓名： | 张颜波 孙保亮 袁慧 杨明峰 牛敬忠 吕国蔚 |
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| 作者单位： | 1. 泰山医学院,附属医院,神经内科,山东,泰安,271000
2. 首都医科大学,低氧医学研究所,北京,100069 |
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| 摘 要： | MAPKs激活通路包括3个被顺序激活的蛋白激酶:MAPKs激酶的激酶(MKKKs)→MAPKs激酶(MKKs)→MAPKs;有MAPK细胞外信号调节激酶(MAPKERK)、C-JUN氨基末端激酶(MAPKJNK)、MAPKP38和MKK5/MAPKERK5等4条通路。吗啡耐受后,MAPKs(ERK、JNK和P38)激活增加。MAPKs激活通路上每个环节的抑制剂均是临床上治疗吗啡耐受的潜在药物。
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| 关 键 词： | 丝裂原活化的蛋白激酶 吗啡耐受 MAPKs抑制剂 |
| 收稿时间： | 2009-4-3 |
| 修稿时间： | 2009-7-7 |
Mitogen-activated protein kinases and morphine tolerance |
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| ZHANG Yan-bo,SUN Bao-liang,YUAN Hui,YANG Ming-feng,NIU Jing-zhong,LU Guo-wei.Mitogen-activated protein kinases and morphine tolerance[J].Basic Medical Sciences and Clinics,2010,30(3):325-328. |
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| Authors: | ZHANG Yan-bo SUN Bao-liang YUAN Hui YANG Ming-feng NIU Jing-zhong LU Guo-wei |
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| Institution: | 1.Dept.of Neurology;the Affiliated Hospital of Taishan Medical College;Taian 271000;2.Institute for Hypoxia Medicine;Capital Medical University;Beijing 100069;China |
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| Abstract: | The MAPKs activation pathway consists of three protein kinases in activation sequence:MAPKs kinase kinases (MKKKs)→,MAPKs kinases (MKKs)→MAPKs and four pathways:extracellular signal-regulated kinase (MAPK~(ERK)),C-JUN N-terminal kinase (MAPK~(JNK)),MAPK~(P38) and MKKS/MAPK~(ERK5) activation pathways.It has been proved that MAPKs(ERK,JNK and P38) are acvtivated in the progress of morphine tolerance.Inhibitors of any element of MAPKs activation pathway may function as a potential clinical medicine for morphine tolerance. |
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| Keywords: | mitogen-activated proteins kinases morphine tolerance MAPKs inhibitiors |
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