Relationship between urine pH and abnormal glucose tolerance in a community‐based study |
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| Authors: | Sakiko Yoshida Teruki Miyake Shin Yamamoto Shinya Furukawa Tetsuji Niiya Hidenori Senba Sayaka Kanzaki Osamu Yoshida Toru Ishihara Mitsuhito Koizumi Masashi Hirooka Teru Kumagi Masanori Abe Kohichiro Kitai Bunzo Matsuura Yoichi Hiasa |
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| Institution: | 1. Department of Gastroenterology, Metabology, Ehime University Graduate School of Medicine, Toon, Ehime, Japan;2. Department of Epidemiology and Preventive Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan;3. Epidemiology and Medical Statistics Unit, Translational Research Center, Ehime University Hospital, Toon, Ehime, Japan;4. Department of Internal Medicine, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan;5. Department of Community Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, Japan;6. Ehime General Health Care Association, Matsuyama, Ehime, Japan |
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| Abstract: | Aims/Introduction The association between urine pH and abnormal glucose tolerance in men and women is unclear; therefore, we carried out a community‐based, cross‐sectional study to investigate sex‐specific associations between these values, possible indicators of prediabetes and type 2 diabetes. Materials and Methods We enrolled 4,945 Japanese individuals (2,490 men and 2,455 women), who had undergone annual health checkups. To investigate the relationship between low urine pH and abnormal glucose tolerance, participants were divided into three groups based on their fasting plasma glucose levels (<6.11 mmol/L, 6.11–6.99 mmol/L and ≥6.99 mmol/L), and three groups based on their glycated hemoglobin levels (≤44.3 mmol/mol, 44.3–47.5 mmol/mol and ≥47.5 mmol/mol). To examine the effects of urine pH on abnormal glucose tolerance, participants were categorized into five groups based on their urine pH (5.0, 5.5, 6.0, 6.5 and ≥7.0). Results Multivariate analysis adjusted for age, body mass index, systolic blood pressure, triglycerides, high‐density lipoprotein cholesterol, uric acid, creatinine and antidiabetic agent use showed significant associations between low urine pH and both high fasting plasma glucose and high glycated hemoglobin levels (P for trend = 0.0260, 0.0075) in men. Furthermore, after the same adjustments, prevalence rates of abnormal glucose tolerance (≥6.11 mmol/L and ≥6.99 mmol/L), increased significantly as urine pH levels decreased (P for trend = 0.0483, 0.0181) in men. In women, a similar trend was observed without a significant difference. Conclusions Low urine pH is significantly associated with abnormal glucose tolerance; therefore, measuring urine pH might prove useful for identifying patients at high risk for diabetes. |
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| Keywords: | Glucose intolerant
pH
Urine |
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