| 人参皂甙对雄性小鼠骨髓细胞染色体的辐射防护作用 |
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| 引用本文： | 刘丽波,李玲,刘鹏来,栗学军,康顺爱. 人参皂甙对雄性小鼠骨髓细胞染色体的辐射防护作用[J]. 吉林大学学报(医学版), 1997, 0(4) |
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| 作者姓名： | 刘丽波 李玲 刘鹏来 栗学军 康顺爱 |
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| 作者单位： | 白求恩医大预防医学院劳动卫生教研室，吉林省卫生防疫站 |
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| 摘 要： | 利用小鼠腹腔注射人参皂甙，观察人参皂甙对Ｘ射线照射小鼠骨髓细胞染色体损伤的防护作用。结果表明，不同浓度的人参皂甙（１２．５～２００ｍｇ／ｋｇ）对０．５ＧｙＸ射线诱发小鼠骨髓细胞染色体畸变具有明显的防护作用，且以５０ｍｇ／ｋｇ防护效果最佳。５０ｍｇ／ｋｇ的人参皂甙对不同剂量（０．５～１．０Ｇｙ）Ｘ射线诱发的小鼠骨髓细胞染色体畸变具有防护作用，可使Ｘ射线诱发的染色体畸变率、细胞畸变率明显降低。为此，我们认为ＧＳ对小鼠骨髓细胞染色体具有保护作用。
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| 关 键 词： | 人参皂甙 X射线照射 骨髓细胞 染色体畸变 防护作用 |
Radioprotective effect of Ginsenoside on chromosome in bone marrow cells of male mouse |
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| Abstract: | Radioprotective effects of GS on chromosome in bone marrow cells of mice were observed in this study.The results were shown as follows:various concentrations of GS (12.5￣200 mg/kg) had obvious protective effects on chromosome aberrations in bone marrow cells induced by 0.5 Gy X-ray,the most effectively protective dose being 50 mg/kg·Fifty GS had protective effect on chromosome aberrations in bone marrow cells exposed to various X-rays doses (0.5￣1.0 Gy),the frequency of chromosome aberrations and aberrant cells were markedly reduced.Our findings suggest that GS has protective effect on chromosome in bone marrow cells of mice. |
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| Keywords: | Ginsenoside X-irradiation Bone marrow cell Chromosome aberration Protective effect |
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