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Identification of endocrine disrupting chemicals activating SXR-mediated transactivation of CYP3A and CYP7A1 |
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| Authors: | Tingting Zhou Shuyan Cong Shiying Sun Hongmiao Sun Renlong Zou Shengli Wang Chunyu Wang Jiao Jiao Kiminobu Goto Hajime Nawata Toshihiko Yanase Yue Zhao |
| Affiliation: | 1. Department of Cell Biology, Key Laboratory of Cell Biology, Ministry of Public Health of China, China Medical University, No. 92 Beier Road, Shenyang 110001, China;2. Department of Neurology, Shengjing Hospital of China Medical University, Sanhao Street 36, Shenyang 110003, China;3. Department of Medicine and Bioregulatory Science (3rd Department of Internal Medicine), Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan;4. Fukuoka Prefectural University, Tagawa City, Fukuoka 825-8585, Japan;5. Department of Endocrinology and Diabetes Mellitus, School of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan |
| Abstract: | |
| Keywords: | EDCs, endocrine disrupting chemicals/environmental endocrine disrupters SXR, steroid xenobiotic receptor in human PXR, pregnane X receptor in rodent (rodent homologue of SXR) PAR, pregnane activated receptor LXRα, liver X receptor alpha FXR, farnesol X receptor PPAR, peroxisome proliferator activator receptor RXR, retinoid X receptor SXRE/PXRE/LXRE/PPRE, SXR/PXR/LXRα/the peroxisome proliferator response element DR3, PXRE in the promoter region of rat CYP3A2 gene ER6, SXRE in the promoter region of human CYP3A4 gene βDR4, LXRE in the promoter region of rat CYP7A1 gene ER, estrogen receptor AR, androgen receptor GR, glucocorticoid receptor |
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