Acoustic Radiation Force Impulse Imaging with Virtual Touch Tissue Quantification: Measurements of Normal Breast Tissue and Dependence on the Degree of Pre-compression |
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Authors: | Sebastian Wojcinski Kathrin Brandhorst Gelareh Sadigh Peter Hillemanns Friedrich Degenhardt |
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Affiliation: | ∗ Department of Obstetrics and Gynecology, Hannover Medical School, Hannover, Germany;† Department of Obstetrics and Gynecology, Franziskus Hospital, Bielefeld, Germany;‡ Department of Radiology, Emory University, Atlanta, Georgia, USA |
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Abstract: | Acoustic radiation force impulse imaging (ARFI) with Virtual Touch tissue quantification (VTTQ) enables the determination of shear wave velocity in meters per second (m/s). We investigated shear wave velocity in normal breast tissue and analyzed the influence of the degree of pre-compression on the measurements. In repeated measurements and with normal pre-compression, the mean shear wave velocity in breast parenchyma was significantly higher than that in breast adipose tissue (3.33 ± 1.18 m/s vs. 2.90 ± 1.10 m/s; p < 0.001; 712 measurements in 89 patients). Furthermore, we found a significant positive correlation between degree of pre-compression and velocity measurements. Shear wave velocities with low, moderate and high pre-compression were 1.89, 3.18 and 4.39 m/s in parenchyma, compared with 1.46, 2.55 and 3.64 m/s in adipose tissue, respectively (p < 0.001; 360 measurements in 60 patients). VTTQ of breast tissue is a feasible method with high accuracy; however, the degree of pre-compression applied may significantly influence the measurements. |
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Keywords: | Acoustic radiation force impulse imaging Virtual Touch tissue quantification Shear wave velocity Breast Elastography |
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