Muscle biopsy findings predictive of malignancy in rare infiltrative dermatomyositis |
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| Authors: | Makoto Uchino Satoshi Yamashita Katsuhisa Uchino Akira Mori Akio Hara Tomohiro Suga Tomoo Hirahara Tatsuya Koide En Kimura Taro Yamashita Akihiko Ueda Ryoichi Kurisaki Junko Suzuki Shoji Honda Yasushi Maeda Teruyuki Hirano Yukio Ando |
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| Affiliation: | 1. Department of Neurology, Faculty of Life Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto 860-0811, Japan;2. Department of Neurology, Jonan Hospital, Mubanchi Jonanmachi, Kumamoto 861-4214, Japan |
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| Abstract: | ObjectiveThe characteristic pathological muscular findings of polymyositis (PM) and dermatomyositis (DM) have been shown to reflect their different pathogeneses. Here, we characterized the muscle biopsy findings of PM and DM patients with or without malignancy.MethodsWe evaluated the muscle biopsy findings of 215 consecutive PM and DM patients admitted to our hospital between 1970 and 2009. Pathology of the lesion biopsy sections was classified into 3 types: endomysial infiltration-type, perivascular infiltration-type, and rare-infiltrative-type.ResultsThere was no difference between the muscle pathology of PM patients with and without malignancy. However, the incidence of rare-infiltrative type muscle pathology in DM patients with malignancy was significantly higher than in those without such tumors (p = 0.0345).ConclusionThe incidence of rare-infiltrative type muscle pathology may be a predictive marker of DM with malignancy. |
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| Keywords: | Dermatomyositis Polymyositis Muscle biopsy findings Malignancy Rare-infiltrative type |
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