Cholestatic fibrosing hepatitis and hepatitis B after bone marrow transplantation |
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Authors: | Suresh R L Merican I Chang K M Yong S M Purusothaman V |
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Affiliation: | Department of Medicine, Hospital Kuala Lumpur. |
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Abstract: | In the setting of transplantation and chronic hepatitis B viral infection there is a unique histological feature termed cholestatic fibrosing hepatitis. The use of nucleoside analogues in the treatment of this condition has been successful. We describe a case of cholestatic fibrosing hepatitis, which occurred after intense immunosuppression for graft versus host disease in a patient with bone marrow transplantations. She was commenced on lamivudine therapy and showed good clinical, biochemical and virological response. However she succumbed due to sepsis. |
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