Overexpression of p53 and HER-2/neu and c-myc in primary fallopian tube carcinoma |
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| Authors: | Chung T K Cheung T H To K F Wong Y F |
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| Institution: | Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, Sha Tin, N.T., Hong Kong. tonychung@cuhk.edu.hk |
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| Abstract: | Primary fallopian tube carcinoma is a rare form of female cancer and the genetic basis of its carcinogenesis remains unclear. Eighteen cases of primary fallopian tube adenocarcinoma were studied. Immunohistochemical staining for p53, HER-2/neu and c-myc genes were performed. Overexpression of p53 was detected in 12 cases (67%), HER-2/neu in 16 cases (89%), and c-myc in 11 cases (61%). The potential relevance of overexpression of the three genes with clinicopathological features was examined, but no significant correlation was found. The high incidence of p53, HER-2/neu and c-myc overexpression in fallopian tube adenocarcinoma suggests these genes may play a role in its tumorigenesis. |
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