| Ursodeoxycholic Acid in the Treatment of Intraheptic Cholestasis of Pregnancy |
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| 引用本文： | 刘玉凌 乔福元 刘海意 刘大艳. Ursodeoxycholic Acid in the Treatment of Intraheptic Cholestasis of Pregnancy[J]. 华中科技大学学报(医学英德文版), 2006, 26(3): 350-352. DOI: 10.1007/BF02829573 |
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| 作者姓名： | 刘玉凌 乔福元 刘海意 刘大艳 |
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| 作者单位： | Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China，Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China，Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China，Department of Obstetrics and Gynecology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China |
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| 摘 要： | Intrahepatic cholestasis of pregnancy(ICP)isone of the most commonliver diseases of pregnan-cy and usually presents in the third tri mester andrarely before25weeks'gestation.It is character-ized by pruritus andjaundice with mildto moderateelevations in transaminases,alkaline phosphatase,bilirubin,and bile acidsinthe absence of other dis-ease processes that could explain these findings.And it is relieved within days after delivery.Al-though the maternal courseis typically benign,thefetuses fac…
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| 关 键 词： | 胆汁淤积 妊娠期 肝功能 治疗 |
| 收稿时间： | 2006-01-26 |
Ursodeoxycholic acid in the treatment of intraheptic cholestasis of pregnancy |
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| Liu Yuling,Qiao Fuyuan,Liu Haiyi,Liu Dayan. Ursodeoxycholic acid in the treatment of intraheptic cholestasis of pregnancy[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2006, 26(3): 350-352. DOI: 10.1007/BF02829573 |
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| Authors: | Liu Yuling Qiao Fuyuan Liu Haiyi Liu Dayan |
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| Affiliation: | Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract: | In order to observe the effect of ursodeoxycholic acid (UDCA) in the treatment of intrahepatic cholestasis of pregnancy (ICP), 68 patients with ICP were equally divided into treatment group and control group at random. The patients in treatment group were administered with UDCA 300 mg three times every day and those in control group received a combination of 10 % glucose, Vitamin C and Inosine. Itching scores, serum ALT and total bile acids (TBA) were measured before, during and after treatment. The results showed that as compared with those before treatment, itching scores, serum ALT and TBA were significantly reduced after treatment (P<0.05). The occurrences of premature labor, fetal asphyxia and meconium staining in amniotic fluid were significantly lower in treatment group than in control group (P<0.05). It was suggested that UDCA was an effective drug in the treatment of ICP. |
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| Keywords: | ursodeoxycholic acid intrahepatic cholestasis pregnancy liver function |
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