| 人参皂甙对大鼠输精管和肛尾肌中α受体效应的影响 |
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| 引用本文： | 周歧新,薛春生,龚晓慧. 人参皂甙对大鼠输精管和肛尾肌中α受体效应的影响[J]. 中药药理与临床, 1989, 0(2) |
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| 作者姓名： | 周歧新 薛春生 龚晓慧 |
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| 作者单位： | 重庆医科大学药理教研室，重庆医科大学药理教研室，邯郸医学院 进修生 |
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| 摘 要： | 人参皂甙(G,10~(-4)g/ml)对离体大鼠输精管(RVD)的正常张力无影响,但能增强电场刺激引起的RVD收缩效应,对抗可乐定(Clo)抑制和育亨宾(Yoh)增强电场刺激引起的RVD收缩。G使苯福林(Phe)对RVD和肛尾肌(RAM)α_1受体作用的量效曲线右移。上述结果进一步支持G在突触前后膜α受体水平上可能均起着调谐剂(modulator)样作用的观点。
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| 关 键 词： | 人参皂甙 突触膜 肾上腺素能α受体 输精管 肛尾肌 |
Effects of Ginsenosides on the Responses mediated by a-Adrenoceptor in Rat Vas Deferens and Portal Vein |
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| Zhou Qixin Xue Chensheng Gong Xiaohui. Effects of Ginsenosides on the Responses mediated by a-Adrenoceptor in Rat Vas Deferens and Portal Vein[J]. Pharmacology and Clinics of Chinese Materia Medica, 1989, 0(2) |
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| Authors: | Zhou Qixin Xue Chensheng Gong Xiaohui |
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| Abstract: | Ginsenosides (G, 10-4g/ml) had no effect on the normal tension of the isolated rat vas deferens (RVD) , but potentiated the twitch response of it induced by field stimulation. G also antagonized the inhibitory effect of clonidine (Clo) and augmentative effect of yohimbine (Yoh) on the twitch response of RVD. Besides, G shifted the dose-response curves of phenylephrine (Phe) to the right in both of RVD and rat, anococcyg-eus muscle (RAM) preparations. All results above indicate that G may act as a. modulator on the level of adrenergic a-receptor in the pre and post- syna ptic membranes. |
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| Keywords: | Ginsenosides Synaptic membrane Adrenergic a-receptor Vas defereris Anococcygeus muscle Project supported by Science Fund of Scientific Committee of Sichuan Province Handan Medical College |
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