| 中枢组胺对戊四氮点燃大鼠海马GABA能神经元的影响 |
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| 引用本文： | 熊英,张晓琴.中枢组胺对戊四氮点燃大鼠海马GABA能神经元的影响[J].脑与神经疾病杂志,2006,14(2):111-113. |
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| 作者姓名： | 熊英 张晓琴 |
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| 作者单位： | 430071,湖北省武汉市武汉大学中南医院神经内科 |
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| 摘 要： | 目的:探讨中枢组胺抗癫痫的作用机制。方法:应用免疫组织化学方法研究中枢组胺对戊四氮(PTZ)致癫痫大鼠海马神经元GABA、GAD67表达的影响。结果:戊四氮致痫组大鼠海马神经元GABA、GAD67的表达量明显低于正常对照组,L-组胺酸干预组明显高于戊四氮致痫组,L-组胺酸干预组与正常对照组之间差异无显著性意义。结论:中枢组胺通过激活海马GABA能神经元来抑制癫痫的发生和发展。
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| 关 键 词： | L-组胺酸 组胺 癫痫 戊四氮 GABA GAD_(67) |
| 文章编号： | 1006-351X（2006）02-0111-03 |
| 收稿时间： | 2005-11-16 |
| 修稿时间： | 2005年11月16 |
Effect of Histamine on γ-Aminobutyric Acid-ergic Neuron of Hippecampus in Seizures Rats Induced by PTZ |
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| XIONG Ying,ZHANG Xiaoqin.Effect of Histamine on γ-Aminobutyric Acid-ergic Neuron of Hippecampus in Seizures Rats Induced by PTZ[J].Journal of Brain and Nervous Diseases,2006,14(2):111-113. |
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| Authors: | XIONG Ying ZHANG Xiaoqin |
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| Abstract: | Objective: To explore the possible mechanism of histamine in seizure. Methods: To study the influence of histamine on -amInobutyric acid immunoreactivity by using immunohistochemistry method. Results: The number and optical density of GABA、 GAD_ 67 in hippocampus of pentylentetrazole(PTZ) group rats was lower than that of control group rats. The number and optical density of GABA, GAD_ 67 in hippocampus of L-histidine group rats was higher than that of PTZ group rats, there was no significant difference between the rats of L-histidine group and control group. Conclusions: Histamine may reinforce the activity and excitability of GABA-ergic neuron in hippocampus. The development and episode of epilepsy were reinforced. |
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| Keywords: | GABA GAD67 |
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