| 高原红细胞增多症患者骨髓端粒酶活性的研究 |
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| 引用本文： | 耿惠,贾乃镛,李占全. 高原红细胞增多症患者骨髓端粒酶活性的研究[J]. 高原医学杂志, 2006, 16(1): 16-18 |
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| 作者姓名： | 耿惠 贾乃镛 李占全 |
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| 作者单位： | 青海大学附属医院血液科,810001;青海大学附属医院血液科,810001;青海大学附属医院血液科,810001 |
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| 摘 要： | 目的研究高原红细胞增多症(HAPC)患者骨髓端粒酶活性的变化。方法用PCR-ELISA法测骨髓单个核细胞端粒酶活性。结果HAPC组患者骨髓端粒酶活性升高,并且与血红蛋白间有显著正相关,随端粒酶活性的增高,HAPC组患者血红蛋白也增高。结论端粒酶活性升高是引起HAPC红细胞增殖的调控机制之一,并且在HAPC形成的慢性代偿到失代偿过程中,端粒酶可能主要在失代偿阶段发挥作用。
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| 关 键 词： | 高原红细胞增多症 端粒酶活性 血红蛋白 |
Study on the Tolemorase Activity of Bone Marrow Cell from HAPC Patients |
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| Geng Hui,Jia NaiYong,Li ZhanQuan. Study on the Tolemorase Activity of Bone Marrow Cell from HAPC Patients[J]. Journal of High Altitude Medicine, 2006, 16(1): 16-18 |
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| Authors: | Geng Hui Jia NaiYong Li ZhanQuan |
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| Affiliation: | Qinghai University Affilaited Hospital |
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| Abstract: | Objective:To study tolemorase activity of bone marrow cell from HAPC patients. Methods: The tolemorase activity was detected by PCR-ELISA. Results:The tolemorase activity increased noticeably and the Hb (hemoglobin) level rose also compared with control group(P<0.05). There is a significant positive correlation (P<0.05) between the tolemirase activity and the Hb. Conclusions: The increased tolemerase activity is a new modulating mechanism for red cell proliferation in HAPC and play a role of action in the duration of de-compensation from compensative stage. |
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| Keywords: | High altitude polycythemia(HAPC) Tolemorase Activity Hb (hemoglobin) ELISA |
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