首页 | 本学科首页   官方微博 | 高级检索  
检索        


Molecular mechanisms of leptin and adiponectin in breast cancer
Authors:Jardé Thierry  Perrier Stéphane  Vasson Marie-Paule  Caldefie-Chézet Florence
Institution:a Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
b Laboratoire SVFp, UFR Pharmacie, CLARA, CRNH-A, 63000 Clermont-Ferrand, France
c EA 4233, Nutrition, Cancérogenèse et Thérapie anti-tumorale, UFR Pharmacie, CLARA, CRNH-A, 63000 Clermont-Ferrand, France
d Unité de Nutrition, Centre Jean-Perrin, 63001 Clermont-Ferrand Cedex 1, France
Abstract:Obesity is associated with an increased risk of breast cancer in postmenopausal women. Accumulating evidence suggests that adipose tissue, which is an endocrine organ producing a large range of factors, may interfere with breast cancer development. Leptin and adiponectin are two major adipocyte-secreted hormones. The pro-carcinogenic effect of leptin and conversely, the anti-carcinogenic effect of adiponectin result from two main mechanisms: a modulation in the signalling pathways involved in proliferation process and a subtle regulation of the apoptotic response. This review provides insight into recent findings on the molecular mechanisms of leptin and adiponectin in mammary tumours, and discusses the potential interplay between these two adipokines in breast cancer.
Keywords:Leptin  Adiponectin  Ob-R  AdipoR1  AdipoR2  Leptin signalling  Adiponectin signalling  Breast cancer
本文献已被 ScienceDirect PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号