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Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC) |
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| Authors: | Campa Daniele Hüsing Anika Chang-Claude Jenny Dostal Lucie Boeing Heiner Kröger Janine Tjønneland Anne Roswall Nina Overvad Kim Dahm Christina C Rodríguez Laudina Sala Núria Pérez Maria José Sánchez Larrañaga Nerea Chirlaque Maria-Dolores Ardanaz Eva Khaw Kay-Tee Wareham Nick Allen Naomi E Travis Ruth C Trichopoulou Antonia Naska Androniki Bamia Christina Palli Domenico Sieri Sabina Tumino Rosario Sacerdote Carlotta van Kranen Henk J Bas Bueno-de-Mesquita H Stattin Pär Johansson Mattias Chajes Veronique Rinaldi Sabina Romieu Isabelle Siddiq Afshan Norat Teresa Riboli Elio Kaaks Rudolf |
| Institution: | a German Cancer Research Center (DKFZ), Heidelberg, Germany b Department of Epidemiology, Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke, Germany c The Danish Cancer Society, Institute of Cancer Epidemiology, Copenhagen, Denmark d Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark e Department of Clinical Epidemiology, Aarhus University Hospital, Aalborg, Denmark f Public Health and Participation Directorate, Health and Health Care Services Council, Asturias, Spain g Catalan Institute of Oncology (ICO) - IDIBELL, Barcelona, Spain h Escuela Andaluza de Salud Pública, Granada, Spain i CIBER en Epidemiología y Salud Pública (CIBERESP), Spain j Public Health Department of Gipuzkoa, Basque Government, Spain k Department of Epidemiology, Regional Health Authority, Murcia, Spain l Public Health Institute of Navarra, Pamplona, Spain m University of Cambridge, Cambridge, UK n MRC Epidemiology Unit, Cambridge, UK o Cancer Epidemiology Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK p WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece q Hellenic Health Foundation, Athens, Greece r Molecular and Nutritional Epidemiology Unit Cancer Research and Prevention Institute - ISPO, Florence, Italy s Nutritional Epidemiology Unit Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy t Cancer Registry and Histopathology Unit, “Civile M.P.Arezzo” Hospital, ASP 7 Ragusa, Italy u CPO-Piemonte Torino, and Human Genetics Foundation, Torino, Italy v Center for Nutrition and Health (CVG) National Institute of Public Health and Environment (RIVM) Bilthoven, The Netherlands w Dept. of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden x International Agency for Research on Cancer, Lyon, France y Imperial College, London, UK |
| Abstract: | A western lifestyle, characterised by low rates of energy expenditure and a high-energy diet rich in animal protein, saturated fats and refined carbohydrates, is associated with high incidence of prostate cancer in men. A high-energy nutritional status results in insulin/IGF signalling in cells, which in turn stimulates synthesis of fatty acids. We investigated whether the genetic variability of the genes belonging to the fatty acid synthesis pathway is related to prostate cancer risk in 815 prostate cancer cases and 1266 controls from the European Prospective Investigation on Cancer (EPIC). Using a tagging approach and selecting 252 SNPs in 22 genes, we covered all the common genetic variation of this pathway. None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk. |
| Keywords: | Fatty acid synthase Prostate cancer Susceptibility to cancer Genetic polymorphisms |
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