Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET |
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| Authors: | Tobias A. Fuchs Jelena R. Ghadri Julia Stehli Catherine Gebhard Egle Kazakauskaite Bernd Klaeser Oliver Gaemperli Michael Fiechter Philipp A. Kaufmann |
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| Affiliation: | 1. Department of Radiology, Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, NUK C 42, 8091, Zurich, Switzerland
2. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland
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| Abstract: | Purpose The aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue. Methods Hypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, apical, septal, lateral and inferior myocardium and CT density was measured in Hounsfield units (HU). Findings were compared to 18F-fluorodeoxyglucose uptake by positron emission tomography (FDG PET), which served as the standard of reference to distinguish scar (<50?% FDG uptake) from viable tissue (≥50?% uptake). Results Visually detected hypodense regions demonstrated a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 74, 97, 84 and 94?%, respectively. A receiver-operating characteristic (ROC) curve analysis revealed a cutoff value of mean HU at <28.8 for predicting scar tissue with an area under the curve of 0.93 yielding a sensitivity, specificity, PPV and NPV of 94, 90, 67 and 99?%, respectively. Conclusion Hypodense regions in unenhanced cardiac CT scans allow accurate identification of nonviable myocardial scar tissue. |
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