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Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy
Authors:S. Yagishita  Y. Itoh  N. Amano  T. Nakano  A. Saitoh
Affiliation:(1) Division of Pathology, Kanagawa Rehabilitation Center, Nahasawa 516, Kanagawa-Ken, Japan;(2) Division of Neurology, Kanagawa Rehabilitation Center, Nahasawa 516, Kanagawa-Ken, Japan;(3) Kanagawa Kinkoh-in Hospital, Kanagawa-Ken, Japan
Abstract:Summary The fine structure of neurofibrillary tangles in the hippocampal gyrus, substantia nigra, pontine nuclei and locus coeruleus of the brain was postmortem studied in a case of progressive supranuclear palsy. Straight tubules and twisted tubules were observed in both the cortical and subcortical neurofibrillary tangles. Most tubules appeared separately in each neuron but a few straight tubules were mixed with the twisted tubules in the cortical tangles. The implication and possible significance of this findings are discussed.
Keywords:Progressive supranuclear palsy  Neurofibrillary tangles  Ultrastructure  Straight tubule  Twisted tubule
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