Ultrastructure of neurofibrillary tangles in progressive supranuclear palsy |
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Authors: | S. Yagishita Y. Itoh N. Amano T. Nakano A. Saitoh |
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Affiliation: | (1) Division of Pathology, Kanagawa Rehabilitation Center, Nahasawa 516, Kanagawa-Ken, Japan;(2) Division of Neurology, Kanagawa Rehabilitation Center, Nahasawa 516, Kanagawa-Ken, Japan;(3) Kanagawa Kinkoh-in Hospital, Kanagawa-Ken, Japan |
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Abstract: | Summary The fine structure of neurofibrillary tangles in the hippocampal gyrus, substantia nigra, pontine nuclei and locus coeruleus of the brain was postmortem studied in a case of progressive supranuclear palsy. Straight tubules and twisted tubules were observed in both the cortical and subcortical neurofibrillary tangles. Most tubules appeared separately in each neuron but a few straight tubules were mixed with the twisted tubules in the cortical tangles. The implication and possible significance of this findings are discussed. |
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Keywords: | Progressive supranuclear palsy Neurofibrillary tangles Ultrastructure Straight tubule Twisted tubule |
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