年轻妇女宫颈癌与HPV感染的关系

目的探讨35岁以下年轻妇女宫颈癌的发生与人乳头状瘤病毒(HPV)感染的关系。方法对1996年10月至2005年11月在我院就诊的96例宫颈癌患者的发病年龄进行分析,并对其肿瘤组织或宫颈分泌物进行HPV检测。结果35岁以下年轻妇女宫颈癌与同期宫颈癌的构成比从1996年的11%上升至2005年的42%。≤35岁宫颈癌患者的HPV阳性率为65%,较>35岁者明显升高,后者为32%。宫颈癌患者的平均发病年龄逐年减小,HPV感染率逐渐升高。结论35岁以下年轻妇女宫颈癌的发病率呈上升趋势,与HPV感染有相关性。故应加强对HPV感染高危人群的监测、随访,做好宫颈癌的早期诊断和治疗。

Analysis on the Relationship between Human Papilloma Virus Infection and Cervical Carcinoma in Young Women

Objective To explore the relationship between human papilloma virus (HPV) infection and the incidence of cervical carcinoma in young women under 35 years old. Method The age group distribution of 96 patients with cervical carcinoma from October 1996 to November 2005 in our hospital was analyzed. The carcinoma tissues and cervical secretion were detected for HPV. Result The constitute ratio of cervical carcinoma in young women under 35 years old to all contemporary cervical carcinoma increased from 11% in 1996 to 42% in 2005. The positive rate of HPV in women under the age of 35 was signficanlly higher than the women with an age of over 35 (65% vs 32%). The mean age of patients with cervical carcinoma decreased gradually at onset, and the HPV infection rate increased gradually. Conclusion The incidence of cervical carcinoma in young women under 35 years old is gradually increasing. The increase is correlated with HPV infection. We must strengthen the monitoring program and the following-up of HPV infection in high-risk populations, and do well in the early diagnosis and treatment of cervical carcinoma.