Conjugated linoleic acid and the control of cancer and obesity |
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| Authors: | Pariza, MW Park, Y Cook, ME |
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| Affiliation: | Food Research Institute, Department of Food Microbiology and Toxicology, University of Wisconsin-Madison, 53706-1187, USA. mwpariza@facstaff.wisc.edu |
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| Abstract: | The effects of conjugated linoleic acid (CLA) in animals are reviewed. Inmost of the CLA preparations that have been investigated to date forbiological activity, two CLA isomers are present in about equalconcentrations: cis-9,trans-11 CLA, and trans-10,cis-12 CLA. The occurrenceof these isomers in foods and their production by rumen microorganisms arediscussed. Potential mechanisms of action as regards the effects of CLA oncancer and body composition are reviewed, including recent evidence thatbody composition changes are produced by the trans-10,cis-12 CLA isomer.Evidence is presented indicating that CLA may modulate cellular response totumor necrosis factor-alpha (TNF- alpha). The mechanistic implications ofthis finding are considered. |
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