| 线粒体钙单向转运体在远距预处理脑保护中的作用及其机制 |
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| 引用本文： | 王士雷,刘志林.线粒体钙单向转运体在远距预处理脑保护中的作用及其机制[J].山东医药,2011,51(39):9-11. |
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| 作者姓名： | 王士雷 刘志林 |
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| 作者单位： | 1. 青岛大学医学院附属医院,山东青岛,266003
2. 青岛市市立医院 |
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| 基金项目： | 国家自然科学基金项目(30972855/C160203); 山东省自然科学基金资助项目(ZR2009CM062) |
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| 摘 要： | 目的探讨肢体缺血预处理（LIP）对脑缺血/再灌注（I/R）损伤保护作用中线粒体钙单向转运体（MCU）的作用及其作用机制。方法将50只I/R损伤模型大鼠随机分为五组。模型组不干预,钌红组、精胺组、LIP组及LIP＋精胺组分别于再灌注前予钌红、精胺、LIP及LIP＋精胺干预。再灌注24 h观察各组神经功能评分,血清丙二醛（MDA）、乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）水平及脑皮质区Bcl-2阳性细胞数。结果钌红组及LIP组神经功能评分及血清MDA、LDH水平明显低于另三组,SOD水平及Bcl-2细胞明显高于另三组,P均〈0.05。结论 CIP对I/R的脑保护作用可能与MCU有关;增强MCU活动可抑制LIP的脑保护作用。
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| 关 键 词： | 远距预处理 线粒体钙单向转运体 脑缺血/再灌注 |
Role of mitochondrial calcium transporters in the remote preconditioning on cerebral ischemia reperfusion injury and its mechanism |
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| WANG Shi-lei,LIU Zhi-lin.Role of mitochondrial calcium transporters in the remote preconditioning on cerebral ischemia reperfusion injury and its mechanism[J].Shandong Medical Journal,2011,51(39):9-11. |
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| Authors: | WANG Shi-lei LIU Zhi-lin |
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| Institution: | WANG Shi-lei1,LIU Zhi-lin(1 The Affiliated Hospital of Medical College,Qingdao University,Qingdao 266003,P.R.China) |
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| Abstract: | Objective To investigate the effect of limb ischemic preconditioning(LIP) on the mitochondrial calcium uniporter(MCU) in the remote preconditioning on cerebral ischemia/reperfusion(I/R) and its mechanism.Methods Fifty I/R model rats were randomly divided into five groups,the cerebral ischemia group was not treated,the ruthenium red group,spermine group,LIP group,LIP +spermine group were treated with ruthenium red,spermine,LIP,LIP +spermine before reperfusion.After 24 h of reperfusion,neurological score,cont... |
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| Keywords: | remote preconditioning mitochondrial calcium uniporter cerebral ischemia/reperfusion |
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