| 胆管癌组织中Survivin和Caspase-3蛋白表达及与预后的关系 |
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| 引用本文： | 许鹏,黄强,刘臣海,谢放,邵峰. 胆管癌组织中Survivin和Caspase-3蛋白表达及与预后的关系[J]. 山东医药, 2011, 51(35): 28-30 |
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| 作者姓名： | 许鹏 黄强 刘臣海 谢放 邵峰 |
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| 作者单位： | 安徽医科大学附属省立医院,合肥,230001 |
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| 摘 要： | 目的探讨Survivin和Caspase-3蛋白在胆管癌组织中的表达及其临床意义。方法采用免疫组织化学方法检测57份胆管癌组织和23份胆管癌癌旁正常胆管组织中Survivin和Caspase-3蛋白的表达情况，分析Survivin和Caspase-3蛋白表达与临床特征及生存期的关系。结果胆管癌组织中Survivin蛋白表达明显高于、Caspase-3蛋白表达明显低于癌旁正常胆管组织（P均〈0．05）。Survivin和Caspase-3蛋白的表达与胆管癌分化程度、TNM分期和淋巴结转移均有关（P均〈0．05）；胆管癌组织中Survivin和Caspase-3蛋白的表达呈负相关（P=0．001，r=-0．415）；Kaplan—Meier生存分析表明，Survivin蛋白阳性者的总体生存时间短于阴性者，而Caspase。3蛋白阳性者明显长于阴性者（均P〈0．05）；COX多因素回归分析显示Survivin蛋白表达是胆管癌患者预后的独立因素（P〈0．05）。结论Survivin蛋白的高表达和Caspase-3蛋白的低表达对胆管癌的发生可能存在协同作用。
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| 关 键 词： | 胆管肿瘤 Survivn蛋白 Caspase-3蛋白 |
Expression of Survivin and Caspase-3 protein and their correlation with prognosis in patients with cholangiocarcinoma |
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| XU Peng,HUANG Qiang,LIU Chen-hai,XIE Fang,SHAO Feng. Expression of Survivin and Caspase-3 protein and their correlation with prognosis in patients with cholangiocarcinoma[J]. Shandong Medical Journal, 2011, 51(35): 28-30 |
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| Authors: | XU Peng HUANG Qiang LIU Chen-hai XIE Fang SHAO Feng |
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| Affiliation: | XU Peng,HUANG Qiang,LIU Chen-hai,XIE Fang,SHAO Feng(Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001,P.R.China) |
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| Abstract: | Objective To explore the expression of Survivin and Caspase-3 protein and their clinicopathological signi-cance in patients with cholangiocarcinoma.Methods The immunohistochemical method was used to analyze the Survivin and Caspase-3 protein expression in 57 cases of cholangiocarcinoma and 23 cases of adjacent noncancerous normal bile duct tissues.The correlation between the expression of Survivin and Caspase-3 protein with the clinicopathological features and prognosis were analyzed.Results The Survivin ex... |
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| Keywords: | bile duct tumor Survivin protein Caspase-3 protein |
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