药物对高原人体运动时NO和NOS的影响

目的：探讨药物对高原人体运动时一氧化氮（NO）及其NO合酶（NOS）的影响；方法：对进驻海拔4100m高原20天的50名健康青年随机分为吸入NO组、红景天组、乙酰唑胺组、西氏胶囊组和对照组，每组10人，在安静时、服（吸入）药前后及踏阶运动后分别检测血中NO、NOS含量；结果：5组青年安静时、服（吸入）药前、踏运动后NO和NOS均无显著性差异（P＞0．05）；运动后较安静时NO组、NO组NO和NOS均增高，有显著性意义（P＜0．05或P＜0．01）；乙酰唑胺组、西氏胶囊组NOS增高，有显著性意义（P＜0．05），NO无统计学意义（P＞0．05）；与对照组比较，NOS均增高显著（P＜0．05或P＜0．01），NO在吸入NO组和红景天组增高显著（P＜0．05），乙酰唑胺组、西氏胶囊组NO、NOS均降低显著（P＜0．05或P＜0．01），红景天组无统计学意义（P＞0．05）；与红景天组比较，乙酰唑胺组、西氏胶囊组NOS降低非常显著（P＜0．01），NO怃统计学意义（P＞0．05）；乙酰唑胺组与西氏动时NOS活性，增加血中NO含量，但吸入NO和服用红景天效果更明显，这可能是吸入NO扩张血管作用、增加组织供血量和红景天抗缺氧机制。

EFFECTS OF DRUGS ON LEVEL OF NO AND NOS IN HEALTH SUBJECTS AT HIGH ALTITUDE

To study the effects of drugs on level of NO and NOS in health subjects exercised at high altitude.Methods:50 health men,who were exposed to altitude of 4 100m for 20 days,were divided into 5 groups of 10 subjects each,group 1,2,3,4 were given NO,Acetazolamide,Pholida,Xi's capsule respecrtively andgroup 5 serves as control.The level of NO and NOS were measured at rest,before-after taking drug and exercise.Results:The changes of level of NO and NOS had not a significant difference(P>0.05) at rest,before taking drugs and after stair-exercise among 5 groups.The level of NO and NOS after exercise were increased(P< 0.05 or 0.01) compared with that at rest,similar results in both before and after taking NO or pholida.The level of NOS was increased(P<0.05) after using Acetazolamide and xi's capsule but level of NO.The level of NOS was higher in group 1,2,3 and 4 than that in control(P<0.01 or 0.05),and level of NO was higher in group 1 and 2(P<0.05) only.Comparison between group 1 and others,the level of NO and NOS were lower in group 3 and 4(P< 0.05 or 0.01),no statistically significant in group 2.Comparison between group 2 and others,the level of NOS were lower(P<0.01) in group 3 and 4.Conclusion:The activor of NOS and level of NO in blood can be increased by four drugs above,apecially after taking NO and Pholida.The results showed that there is a better effect of NO and Pholida on altitude hypoxia.