基质金属蛋白酶9与原发性高血压患者血压昼夜节律的相关性分析 |
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引用本文: | 郑翔,苏雨江,梁宁,郑青. 基质金属蛋白酶9与原发性高血压患者血压昼夜节律的相关性分析[J]. 海南医学, 2010, 21(15): 6-8 |
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作者姓名: | 郑翔 苏雨江 梁宁 郑青 |
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作者单位: | 海口市人民医院,中南大学湘雅医学院附属海口医院心血管内科,海南,海口,570208;海口市人民医院,中南大学湘雅医学院附属海口医院心血管内科,海南,海口,570208;海口市人民医院,中南大学湘雅医学院附属海口医院心血管内科,海南,海口,570208;海口市人民医院,中南大学湘雅医学院附属海口医院心血管内科,海南,海口,570208 |
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摘 要: | 目的探讨原发性高血压(EH)患者血清基质金属蛋白酶9(MMP-9)与血压昼夜节律模式改变的相关性。方法随机选择老年原发性高血压患者80例,其中杓型血压组27例作为对照,非杓型血压组27例、反杓型血压组26例作为研究对象,采用酶联免疫吸附试验法分别测定三组患者血清MMP-9水平,并进行对比分析。结果非杓型血压组、反杓型血压组患者的血清MMP-9水平高于对照组,差异有统计学意义(P〈0.01,t=3.997、2.798),MMP-9与患者年龄、平均脉搏、人院收缩压、人院舒张压等基本临床资料无显著相关性(P〉0.05)。结论非杓型血压组、反杓型血压组患者血清MMP-9表达增加,较杓型血压组患者发生心血管疾病损害的危险性增加,非杓型血压组与反杓型血压组患者血清MMP-9表达差异无统计学意义。
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关 键 词: | 原发性高血压 基质金属蛋白酶9 血压昼夜节律 |
Relationship between matrix metalloproteinases-9 and circadian rhythm of blood pressure in patients with essential hypertension |
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Affiliation: | ZHENG Xiang , SU Yu -jiang , LIANG Ning , et al. (Department of Cardiology, the People' s Hospital of Haikou City, Haikou 570208, Hainan, CHINA) |
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Abstract: | Objective To observe the relationship between the serum level of matrix metalloproteinase -9 ( MMP - 9) and circadian rhythm of ambulatory blood pressure in patients with essential hypertension. Methods According to ambulatory blood pressure, 80 patients with essential hypertension were divided into three groups: dipper group ( n = 27 ), non - dipper group ( n = 27 ), reversed - dipper group ( n = 26). The serum levels of MMP - 9 were detected by ELISA method in 80 senile hypertensive patients. Results The hypertension patiems in non - dipper group and reversed - dipper group exhibited higher levels of MMP - 9 (P 〈 0.01 ) than in the dipper group. The serum level of MMP - 9 was not significantly and positively eorrelated with HDL - C, LDL - C, age, and so on. Conclusion There exists the development of cardiovascular diseases in abnormal diurnal rhythm of blood pressure in essemial hypertension. |
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Keywords: | Essential hypertension Matrix metalloproteinase Blood Pressure Circadian Rhythm |
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