羟基喜树碱联合化疗治疗晚期消化系统癌的临床研究

目的观察羟基喜树碱(HCPT)联合醛氢叶酸(LV)、5-氟脲嘧啶(5-FU)治疗晚期消化系统癌的疗效和不良反应。方法将67例晚期消化系统癌随机分成HCPT+LV+5-FU化疗组35例和单纯LV+5-FU化疗组32例,对其疗效及毒副反应进行观察比较与分析,所有病人均接受2个疗程以上的治疗。结果治疗组有效率(CR+PR)40.0%,对照组有效率15.6%,两者间差异有显著性意义(P<0.05)。毒性反应主要是消化道反应和血液学毒性,两组无显著性差异(P>0.05)。结论羟基喜树碱联合化疗治疗晚期消化系统癌提高了疗效,不良反应并未增加,值得进一步的前瞻性研究。

Preliminary study on HCPT combined with chemotherapy in the treatment of digestive system neoplasms patients

Objective To assess the anti-tumor efficacy and safety of chemo th erapy of HCPT with leucovorin and 5-fluorouracil in the treatment of digestive system neoplasms. Methods 67 cases in-hospital various digestive system neoplas ms patients were randomly divided as two groups: treated group (35 cases) and co ntrolled group (32 cases). Treated group used HCPT with leucovorin and 5-fluoro uracil,controlled group with leucovorin and 5-fluorouracil. Results The respons e rate(CR+PR) were 40.0%in treated group and 15.6%in controlled group (P<0.05 ).The main toxicity was gastrointestinal reaction and myelosuppression.All the s ide effects were mild and tolerable. Conclusion HLF regimen may be promising for treating digestive system neoplasms. Further studies are warranted.